Microneedle and chip

Abstract

A microneedle and a chip are disclosed for extraction fluids. The microneedle is provided on a substrate and comprises an elongated body extending from a distal end with a bevel to a proximal end on the substrate along a longitudinal axis. The elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path. The proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end.

1 . A microneedle provided on a substrate, comprising:
 an elongated body extending from a distal end thereof with a bevel to a proximal end on the substrate along a longitudinal axis, wherein:
 the elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path; 
 the proximal end is connected to the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate; 
 wherein the cross-sectional area of the capillary bore comprises a triangular cross-section in a perpendicular direction relative the longitudinal direction of the microneedle. 
   
     
     
         2 . A microneedle according to  claim 1 , wherein the triangular cross-section of the capillary bore further comprises at least one rounded corner. 
     
     
         3 . A microneedle according to  claim 1 , wherein the triangular cross-section of the capillary bore comprises a convex base connected to straight sections via two rounded corners. 
     
     
         4 . A microneedle according to  claim 1 , wherein the capillary bore comprises a hydrophilic surface. 
     
     
         5 . A microneedle according to  claim 1 , wherein the fluid channel is configured to provide an under-pressure, relative the atmospheric pressure, to the capillary bore, whereby fluid flow through the capillary bore is promoted. 
     
     
         6 . A microneedle according to  claim 1 , wherein the elongated body further comprises a lateral hole from a side of the microneedle and extends in a radial direction relative the longitudinal direction, wherein the lateral hole is in fluid communication with the capillary hole. 
     
     
         7 . A chip, comprising:
 a plurality of microneedles integrally formed on a substrate, each microneedle comprising:
 an elongated body extending from a distal end thereof with a bevel to a proximal end thereof on the substrate along a longitudinal axis; 
 wherein the elongated body comprises a capillary bore extending in a longitudinal direction thereof and defining a fluid path, wherein the cross-sectional area of the capillary bore comprises a triangular cross-section in a perpendicular direction relative the longitudinal direction of the microneedle; and 
 wherein the proximal end is integrally formed with the substrate and the first fluid path is in fluid communication with a fluid channel of the substrate. 
   
     
     
         8 . A chip according to  claim 7 , wherein the substrate comprises a fluid channel which forms a fluid path, wherein the fluid channel has a width larger than the depth of the fluid channel. 
     
     
         9 . A chip according to  claim 7 , wherein at least a part of a wall of the capillary bore forms a part of a wall of the fluid channel. 
     
     
         10 . A chip according to  claim 7 , wherein the fluid channel comprises directional changes with an angle (Θ) smaller than 90 degrees. 
     
     
         11 . A chip according to  claim 7 , further comprising a base substrate, which comprises a fluid port in fluid communication with the fluid channel, and which opens in the backside of the base substrate. 
     
     
         12 . A chip according to  claim 11 , wherein the fluid port comprises an increasing area in the longitudinal direction of the port towards the back of the base substrate. 
     
     
         13 . A chip according to  claim 7 , wherein the base substrate is operatively connected to the substrate by means of bonding. 
     
     
         14 . A chip according to  claim 7 , wherein the plurality of microneedles are surrounded by an edge which is in level with the distal end of the microneedles.