Compositions and methods for the treatment of presbyopia

Abstract

The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine. The compositions optionally contain a surfactant and a viscosity agent.

What is claimed is: 
     
         1 . A method of treating presbyopia comprising administering to a subject in need thereof an ophthalmological composition comprising aceclidine. 
     
     
         2 . The method of  claim 1 , wherein aceclidine is at a concentration from about 0.25% to about 2.5% w/v, wherein w/v denotes weight by total volume of the composition. 
     
     
         3 . The method of  claim 1 , wherein aceclidine is at a concentration from about 0.75% to about 2.5% w/v. 
     
     
         4 . A method of treating presbyopia comprising administering to a subject in need thereof an ophthalmological composition comprising aceclidine and a viscosity agent. 
     
     
         5 . The method of  claim 4 , wherein aceclidine is at a concentration from about 0.25% to about 2.5% w/v, wherein w/v denotes weight by total volume of the composition. 
     
     
         6 . The method of  claim 4 , wherein aceclidine is at a concentration from about 0.75% to about 2.5% w/v. 
     
     
         7 . A method of treating presbyopia comprising administering a composition comprising aceclidine and one or more nonionic surfactants to a subject in need thereof. 
     
     
         8 . The method of  claim 7 , wherein aceclidine is at a concentration from about 0.25% to about 2.5% w/v, wherein w/v denotes weight by total volume of the composition. 
     
     
         9 . The method of  claim 7 , wherein aceclidine is at a concentration from about 0.75% to about 2.5% w/v. 
     
     
         10 . A method of treating low regular astigmatism, low or high irregular astigmatism, keratoconic ectasia, night vision halos/starbursts, night vision reduced contrast, and low myopia, or hyperopia, with or without astigmatism, comprising administering to a subject in need thereof an ophthalmological composition comprising aceclidine.