US2022033757A1PendingUtilityA1

Open-top microfluidic device with structural anchors

76
Assignee: EMULATE INCPriority: Dec 4, 2015Filed: Oct 5, 2021Published: Feb 3, 2022
Est. expiryDec 4, 2035(~9.4 yrs left)· nominal 20-yr term from priority
Inventors:Daniel LevnerChristopher David HinojosaNorman WenAntonio VaroneJustin NguyenLina WilliamsonS. Jordan KernsCatherine KaralisGeraldine HamiltonCarol Lucchesi
B01L 3/5027C12M 3/04G01N 33/5008G01N 33/5005B01L 2300/0681C12N 5/0619C12M 35/08C12N 5/0698C12M 23/16C12N 5/069B01L 3/502761B01L 3/502715C12N 5/0697C12M 23/38C12N 5/0622G01N 33/54366C12N 2501/165G01N 33/50C12M 25/02C12N 5/0656B01L 2200/0668C12M 23/42B01L 2300/0645C12N 5/0629C12N 5/0688G01N 33/5082B01L 2300/0887C12M 21/08C12M 35/04
76
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

Claims

exact text as granted — not AI-modified
1 - 46 . (canceled) 
     
     
         47 . A microfluidic device, comprising i) a chamber with a lumen and a fluidic cover comprising a microfluidic channel, ii) a membrane below said chamber, wherein said fluidic cover is configured to removably cover and close said chamber. 
     
     
         48 . The microfluidic device of  claim 47 , wherein said membrane is a porous membrane. 
     
     
         49 . The microfluidic device of  claim 47 , wherein said chamber comprises cells. 
     
     
         50 . The microfluidic device of  claim 47 , wherein said chamber comprises a gel. 
     
     
         51 . The microfluidic device of  claim 47 , wherein said chamber is configured for fluid flow. 
     
     
         52 . The microfluidic device of  claim 47 , wherein said chamber is circular. 
     
     
         53 - 60 . (canceled)

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.