Method and apparatus for providing information associated with immune phenotypes for pathology slide image

Abstract

The present disclosure relates to a method, performed by at least one computing device, for providing information associated with immune phenotype for pathology slide image. The method may include obtaining information associated with immune phenotype for one or more regions of interest (ROIs) in a pathology slide image, generating, based on the information associated with the immune phenotype for one or more ROIs, an image indicative of the information associated with the immune phenotype, and outputting the image indicative of the information associated with immune phenotype.

What is claimed is: 
     
         1 . A method, performed by at least one computing device, for providing information associated with immune phenotype for pathology slide image, comprising:
 obtaining information associated with immune phenotype for one or more regions of interest (ROIs) in a pathology slide image;   generating, based on the information associated with the immune phenotype for one or more ROIs, an image indicative of the information associated with the immune phenotype; and   outputting the image indicative of the information associated with the immune phenotype.   
     
     
         2 . The method according to  claim 1 , wherein the one or more ROIs are determined based on a detection result for one or more target items for the pathology slide image. 
     
     
         3 . The method according to  claim 2 , wherein the one or more ROIs include at least some regions in the pathology slide image that satisfy a condition associated with the one or more target items. 
     
     
         4 . The method according to  claim 2 , wherein the one or more ROIs are regions being output upon input of the detection result for the one or more target items for the pathology slide image or the pathology slide image to a region-of-interest (ROI) extraction model, and
 the ROI extraction model is trained to output a reference ROI upon input of the detection result for one or more target items for a reference pathology slide image or a reference pathology slide image.   
     
     
         5 . The method according to  claim 1 , wherein the obtaining includes obtaining the immune phenotype of the one or more ROIs,
 the generating includes generating an image including a visual representation corresponding to the immune phenotype of the one or more ROIs, and   the immune phenotype includes at least one of immune inflamed, immune excluded, or immune desert.   
     
     
         6 . The method according to  claim 5 , wherein the outputting includes outputting the one or more ROIs in the pathology slide image together with the image including the visual representation. 
     
     
         7 . The method according to  claim 5 , wherein the outputting includes overlaying the image including the visual representation on the one or more ROIs in the pathology slide image. 
     
     
         8 . The method according to  claim 1 , wherein the obtaining includes obtaining one or more immune phenotype scores for the one or more ROIs,
 the generating includes generating an image including a visual representation corresponding to the one or more immune phenotype scores, and   the one or more immune phenotype scores include at least one of a score for immune inflamed, a score for immune excluded, or a score for immune desert.   
     
     
         9 . The method according to  claim 8 , wherein the outputting includes outputting the one or more ROIs in the pathology slide image together with the image including the visual representation. 
     
     
         10 . The method according to  claim 8 , wherein the outputting includes overlaying the image including the visual representation on the one or more ROIs in the pathology slide image. 
     
     
         11 . The method according to  claim 1 , wherein the obtaining includes obtaining a feature associated with one or more immune phenotypes for the one or more ROIs,
 the generating includes generating an image including a visual representation corresponding to the feature associated with the one or more immune phenotypes, and   the feature associated with the one or more immune phenotypes includes at least one of a statistical value or a vector associated with the immune phenotype.   
     
     
         12 . The method according to  claim 11 , wherein the outputting includes outputting the one or more ROIs in the pathology slide image together with the image including the visual representation. 
     
     
         13 . The method according to  claim 11 , wherein the outputting includes overlaying the image including the visual representation on the one or more ROIs in the pathology slide image. 
     
     
         14 . The method according to  claim 1 , further comprising:
 obtaining a detection result for one or more target items from the pathology slide image;   generating an image indicative of the detection result for one or more target items; and   outputting the image indicative of the detection result for one or more target items.   
     
     
         15 . A non-transitory computer-readable recording medium storing a computer program for executing, on a computer, the method for providing the information associated with the immune phenotype for the pathology slide image according to  claim 1 . 
     
     
         16 . A computing device comprising:
 a memory storing one or more instructions; and   a processor configured to execute the stored one or more instructions to:
 obtain information associated with immune phenotype for one or more regions of interest (ROIs) in a pathology slide image; 
 generate, based on the information associated with the immune phenotype for one or more ROIs, an image indicative of the information associated with the immune phenotype; and 
 output the image indicative of the information associated with the immune phenotype. 
   
     
     
         17 . The computing device according to  claim 16 , wherein the processor is further configured to:
 obtaining the immune phenotype of the one or more ROIs; and   generate an image including a visual representation corresponding to the immune phenotype of the one or more ROIs, and   the immune phenotype includes at least one of immune inflamed, immune excluded, or immune desert.   
     
     
         18 . The computing device according to  claim 17 , wherein the processor is further configured to output the one or more ROIs in the pathology slide image together with the image including the visual representation. 
     
     
         19 . The computing device according to  claim 17 , wherein the processor is further configured to overlay the image including the visual representation on the one or more ROIs in the pathology slide image. 
     
     
         20 . The computing device according to  claim 16 , wherein the processor is further configured to:
 obtain one or more immune phenotype scores for the one or more ROIs; and   generate an image including a visual representation corresponding to the one or more immune phenotype scores, and   the one or more immune phenotype scores include at least one of a score for immune inflamed, a score for immune excluded, or a score for immune desert.