Oral rehydration composition with oligosaccharides

Abstract

The general inventive concepts are directed to compositions and methods for the prevention and treatment of dehydration. Provided herein are nutritional compositions including oral rehydration compositions. Certain embodiments of the nutritional compositions have an acidic pH, and comprise a digestible carbohydrate, sodium, citrate, and an oligosaccharide selected from a fucosylated oligosaccharide and an N-acetylated oligosaccharide.

1 - 42 . (canceled) 
     
     
         43 . An oral rehydration composition in the form of a reconstitutable powder, the composition comprising:
 a fucosylated human milk oligosaccharide, wherein the fucosylated human milk oligosaccharide is the sole human milk oligosaccharide;   a digestible carbohydrate in addition to the human milk oligosaccharide; and   sodium.   
     
     
         44 . The oral rehydration composition of  claim 43 , wherein the fucosylated human milk oligosaccharide is 2′-fucosyllactose. 
     
     
         45 . The oral rehydration composition of  claim 44 , wherein, when the oral rehydration composition is reconstituted into a liquid formulation having a sodium concentration of 10 mEq to 100 mEq per liter, the 2′-fucosyllactose is present in the liquid formulation in an amount of 10 mg to 5000 mg per liter. 
     
     
         46 . The oral rehydration composition of  claim 43 , wherein, when the oral rehydration composition is reconstituted into a liquid formulation having a sodium concentration of 10 mEq to 100 mEq per liter, the digestible carbohydrate is present in the liquid formulation in an amount of up to about 2.5% by weight. 
     
     
         47 . The oral rehydration composition of  claim 43 , wherein the digestible carbohydrate is selected from the group consisting of dextrose, maltodextrin, starch, isomaltulose, sucromalt, rice syrup, rice syrup solids, and combinations thereof. 
     
     
         48 . The oral rehydration composition of  claim 47 , wherein the digestible carbohydrate is dextrose. 
     
     
         49 . The oral rehydration composition of  claim 47 , wherein the digestible carbohydrate is maltodextrin. 
     
     
         50 . The oral rehydration composition of  claim 43 , wherein the sodium is selected from the group consisting of sodium chloride, sodium phosphate, sodium citrate, sodium carbonate, sodium bicarbonate, sodium hydroxide, sodium ascorbate and combinations thereof. 
     
     
         51 . The oral rehydration composition of  claim 43  further comprising chloride. 
     
     
         52 . The oral rehydration composition of  claim 51 , wherein the chloride is selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and combinations thereof. 
     
     
         53 . The oral rehydration composition of  claim 51 , wherein, when the oral rehydration composition is reconstituted into a liquid formulation having a sodium concentration of 10 mEq to 100 mEq per liter, the chloride is present in the liquid formulation in an amount of 5 mEq to 90 mEq per liter. 
     
     
         54 . The oral rehydration composition of  claim 43  further comprising potassium. 
     
     
         55 . The oral rehydration composition of  claim 54 , wherein the potassium is selected from the group consisting of potassium chloride, potassium phosphate, potassium citrate, potassium carbonate, potassium bicarbonate, potassium hydroxide, and combinations thereof. 
     
     
         56 . The oral rehydration composition of  claim 54 , wherein, when the oral rehydration composition is reconstituted into a liquid formulation having a sodium concentration of 10 mEq to 100 mEq per liter, the potassium is present in the liquid formulation in an amount of 3 mEq to 100 mEq per liter. 
     
     
         57 . The oral rehydration composition of  claim 43  further comprising magnesium. 
     
     
         58 . The oral rehydration composition of  claim 43  further comprising vitamin C. 
     
     
         59 . The oral rehydration composition of  claim 43  further comprising citrate. 
     
     
         60 . The oral rehydration composition of  claim 59 , wherein the citrate is selected from the group consisting of potassium citrate, sodium citrate, zinc citrate, and combinations thereof. 
     
     
         61 . The oral rehydration composition of  claim 59 , wherein, when the oral rehydration composition is reconstituted into a liquid formulation having a sodium concentration of 10 mEq to 100 mEq per liter, the citrate is present in the liquid formulation in an amount of 1 mEq to 200 mEq per liter. 
     
     
         62 . A liquid oral rehydration formulation reconstituted from a reconstitutable powder, the formulation comprising:
 a fucosylated human milk oligosaccharide, wherein the fucosylated human milk oligosaccharide is the sole human milk oligosaccharide;   a digestible carbohydrate in addition to the human milk oligosaccharide; and   sodium in an amount of 10 mEq to 100 mEq per liter.