Advanced tissue engineering system

Abstract

The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

What is claimed is: 
     
         1 . A product chamber assembly, comprising:
 a bioreactor, the bioreactor having a bioreactor lid connected to a vertical chamber and a bioreactor base, the bioreactor containing a conical cell collector;   a set of flexible bags that are used to contain processing fluids and for automated flow to and from the bioreactor, wherein at least one flexible bag is in fluid communication with the bioreactor; and   at least one biosensor for monitoring parameters of the flexible bags and cells within the bioreactor, the at least one biosensor relaying variable parameter information to a microprocessor to process the parameters and dynamically adjust and adapt to specific needs of the cells.   
     
     
         2 . The product chamber assembly of  claim 1 , further comprising a temperature controller to allow for reduced temperature operation. 
     
     
         3 . The product chamber assembly of  claim 1 , further comprising a collection reservoir. 
     
     
         4 . The product chamber assembly of  claim 1 , further comprising a fluid pump. 
     
     
         5 . The product chamber assembly of  claim 1 , further comprising one or more fluid control valves.