Compositions for the treatment of autodigestion

Abstract

Compositions for the treatment of shock, autodigestion, multi-organ failure, intestinal ischemia, or intestinal hypoperfusion are provided.

1 . A composition comprising tranexamic acid, PEG, glucose, and one or more electrolytes. 
     
     
         2 . The composition of  claim 1 , wherein the PEG is PEG 3350. 
     
     
         3 . The composition of  claim 2 , wherein the composition comprises a non-colonic cleansing amount of PEG 3350. 
     
     
         4 . The composition of  claim 2 , wherein the composition comprises about 7.8 g of tranexamic acid, about 50.3 g of PEG 3350, about 40 g of glucose, about 5.7 g of sodium sulfate, about 1.7 g of sodium bicarbonate, about 1.5 g of sodium chloride, and about 0.7 g of potassium chloride. 
     
     
         5 . The composition of  claim 2 , wherein the composition comprises about 7.5 g of tranexamic acid, about 32.5 g of PEG 3350, about 28 g of glucose, about 4.0 g of sodium sulfate, about 1.2 g of sodium bicarbonate, about 1.0 g of sodium chloride, and about 0.5 g of potassium chloride. 
     
     
         6 . The composition of  claim 1 , wherein the composition comprises about 7.8 g of tranexamic acid and about 40 g of glucose. 
     
     
         7 . The composition of  claim 1 , wherein the composition comprises about 7.5 g of tranexamic acid and about 28 g of glucose. 
     
     
         8 . The composition of  claim 1 , wherein the composition is formulated as an aqueous solution. 
     
     
         9 . The composition of  claim 4 , wherein the composition is formulated as a 1000 mL aqueous solution. 
     
     
         10 . The composition of  claim 5 , wherein the composition is formulated as a 700 mL aqueous solution. 
     
     
         11 - 22 . (canceled) 
     
     
         23 . A kit comprising: the components tranexamic acid, PEG, glucose, and one or more electrolytes, wherein at least one of the components tranexamic acid, PEG, glucose, and one or more electrolytes is in a separate container from at least one of the other components tranexamic acid, PEG, glucose, and one or more electrolytes; and instructions to combine the components tranexamic acid, PEG, glucose, and one or more electrolytes in a single composition. 
     
     
         24 . The kit of  claim 23 , wherein the tranexamic acid, PEG, and one or more electrolytes are in a first container, and the glucose is in a second container. 
     
     
         25 . The kit of  claim 23 , wherein the kit further comprises instructions to reconstitute the components in water. 
     
     
         26 . The kit of  claim 24 , wherein the first container comprises about 7.8 g of tranexamic acid, about 50.3 g of PEG 3350, about 5.7 g of sodium sulfate, about 1.7 g of sodium bicarbonate, about 1.5 g of sodium chloride, and about 0.7 g of potassium chloride, and wherein the second container comprises about 40 g of glucose. 
     
     
         27 . The kit of  claim 24 , wherein the first container comprises about 7.5 g of tranexamic acid, about 32.5 g of PEG 3350, about 4.0 g of sodium sulfate, about 1.2 g of sodium bicarbonate, about 1.0 g of sodium chloride, and about 0.5 g of potassium chloride, and wherein the second container comprises about 28 g of glucose. 
     
     
         28 . The kit of  claim 26 , wherein the kit further comprises instructions to reconstitute the tranexamic acid, PEG, glucose, and one or more electrolytes with water to 1000 mL. 
     
     
         29 . The kit of  claim 27 , wherein the kit further comprises instructions to reconstitute the tranexamic acid, PEG, glucose, and one or more electrolytes with water to 700 mL. 
     
     
         30 . The kit of  claim 24 , wherein the kit comprises instructions to administer the combined components orally or via a nasogastric, orogastric, nasojejunal, orojejunal, nasoduodenal, or percutaneous endoscopic gastrostomy tube or catheter.