Methods of acute restoration of vascular compliance

Abstract

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

1 - 24 . (canceled) 
     
     
         25 . A method of restoring vascular compliance in a diseased blood vessel, comprising:
 inserting a delivery system into the blood vessel;
 applying a bolus of a composition comprising a 4-amino-1,8-naphthalimide compound to the blood vessel; and 
 activating the composition with a sufficient amount of electromagnetic energy to restore the vascular compliance of the blood vessel; wherein the 4-amino-1,8-naphthalimide compound comprises a compound of formula (II): 
   
       
         
           
           
               
               
           
         
         wherein R, R′, and Q are each independently selected from the group consisting of straight-chain and branched chain alkyl groups having from 2 to 200 carbons, optionally substituted with one or more ether, amide or amine groups. 
       
     
     
         26 . The method of  claim 25 , wherein the blood vessel is an artery or a vein. 
     
     
         27 . The method of  claim 25 , wherein the vascular compliance of the blood vessel is restored to its native compliance within seconds to about 120 days after the activating step. 
     
     
         28 . The method of  claim 25 , wherein the composition further comprises one or more excipients, buffers, carriers, stabilizers, preservatives, solvents and/or bulking agents. 
     
     
         29 . The method of  claim 28 , wherein the composition further comprises a solvent. 
     
     
         30 . The method of  claim 29 , wherein the solvent is phosphate buffered saline. 
     
     
         31 . The method of  claim 29 , wherein the solvent comprises dimethylformamide or isopropyl alcohol. 
     
     
         32 . The method of  claim 29 , wherein the 1,4-amino-8-napthalimide compound is present in a concentration from about 0.01 mg/mL to about 100 mg/mL. 
     
     
         33 . The method of  claim 29 , wherein the 1,4-amino-8-napthalimide compound is present in a concentration from about 0.1 mg/mL to about 50 mg/mL. 
     
     
         34 . The method of  claim 29 , wherein the 1,4-amino-8-napthalimide compound is present in a concentration from about 1 mg/mL to about 30 mg/mL. 
     
     
         35 . The method of  claim 25 , wherein the electromagnetic energy comprises blue light. 
     
     
         36 . The method of  claim 25 , wherein the composition further comprises acetate ions. 
     
     
         37 . The method of  claim 30 , wherein the composition further comprises acetate ions. 
     
     
         38 . The method of  claim 31 , wherein the composition further comprises acetate ions. 
     
     
         39 . The method of  claim 25 , wherein R and R′ are each CH 2 (CH 2 OCH 3 ) 3 CH 2 NH 2  and Q is CH 2 (CH 2 OCH 2 ) 2 CH 2 .