Method for Producing Hydrogels Coupling High Elastic Modulus and Absorbance

Abstract

The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

1 . A citric acid crosslinked carboxymethylcellulose, which is produced by a method comprising crosslinking carboxymethylcellulose with citric acid, wherein said carboxymethylcellulose has a viscosity as a 1% (wt/wt) aqueous solution at 25° C. of greater than 6000 cps and a polydispersity index less than 8. 
     
     
         2 - 53 . (canceled)