Method for treating or preventing inflammation

Abstract

The present invention relates to an extract obtained from or obtainable from Rubus idaeus, a composition comprising an extract obtained from or obtainable from Rubus idaeus, processes for providing such an extract, and methods and uses relating to such extracts. In particular, the present invention relates to an extract or composition for use in treating or preventing inflammation, such as arthritis and joint inflammation.

1 . A liquid or solid oral dosage form comprising a composition for treating inflammation associated with arthritis or joint swelling, the composition comprising a therapeutically effective amount of a  Rubus idaeus  extract, wherein the extract comprises
 (i) from about 1% to about 40% by weight of phenolic compounds;   (ii) from about 0.5% to about 7% by weight of hydroxycimmanic acid and ellagic compounds; and   (iii) from about 1% to about 15% by weight of flavonoid compounds.   
     
     
         2 . The oral dosage form of  claim 1 , wherein the solid oral dosage form is selected from the group consisting of hard capsules, soft capsules, tablets, troches, dragees, pills, lozenges, powders, and granules; and wherein the liquid oral dosage form is selected from the group consisting of emulsions, elixirs, aqueous suspensions, oily suspensions, solutions, and syrups. 
     
     
         3 . The oral dosage form of  claim 1 , wherein the extract is obtained from the aerial part of  Rubus idaeus.    
     
     
         4 . The oral dosage form of  claim 3 , wherein the aerial part of the  Rubus idaeus  comprises the stems of the  Rubus idaeus.    
     
     
         5 . The oral dosage form of  claim 3 , wherein the aerial part of the  Rubus idaeus  comprises the leaves of the  Rubus idaeus.    
     
     
         6 . The oral dosage form of  claim 1 , wherein the  Rubus idaeus  extract is derived in the absence was other plants of the  Rubus  genus. 
     
     
         7 . The oral dosage form of  claim 1 , wherein the  Rubus idaeus  extract comprises an aqueous extract. 
     
     
         8 . The oral dosage form of  claim 1 , wherein the  Rubus idaeus  extract comprises an ethanol extract. 
     
     
         9 . The oral dosage form of  claim 1 , wherein the composition comprises a functional food composition, a pharmaceutical composition, or a veterinary composition. 
     
     
         10 . The oral dosage form of  claim 9 , wherein the composition comprises a pharmaceutical composition comprising a pharmaceutically acceptable excipient. 
     
     
         11 . The oral dosage form of  claim 10 , wherein the pharmaceutically acceptable excipient is selected from adjuvants, carriers, diluents, and combinations thereof. 
     
     
         12 . The oral dosage form of  claim 11 , wherein the carriers are selected from solid fillers, sterile aqueous solutions, and organic solvents. 
     
     
         13 . The oral dosage form of  claim 9 , wherein the composition comprises a veterinary composition comprising a veterinary acceptable excipient. 
     
     
         14 . The oral dosage form of  claim 13 , wherein the veterinary acceptable excipient is selected from adjuvants, carriers, diluents, and combinations thereof. 
     
     
         15 . The oral dosage form of  claim 14 , wherein the carriers are selected from solid fillers, sterile aqueous solutions, and organic solvents. 
     
     
         16 . The oral dosage form of  claim 9 , wherein the functional food composition is selected from the group consisting of a feed, a food, a pet food, a feed supplement, a food supplement, and a pet food supplement. 
     
     
         17 . The oral dosage form of  claim 1 , wherein the composition can provide the extract in an amount from about 10 mg/day to about 2000 mg/day. 
     
     
         18 . The oral dosage form of  claim 1 , wherein the composition can provide the extract in an amount from about 500 mg/day to about 1500 mg/day. 
     
     
         19 . The oral dosage form of  claim 1 , wherein the composition can provide the extract in an amount of about 1000 mg/day. 
     
     
         20 . The oral dosage form of  claim 1 , wherein the composition comprises 10 mg, 20 mg, 30, mg, 40 mg, 50 mg, 60 mg, 70 mg, 80 mg, 100 mg, 250 mg, 500 mg, 750, 1000 mg, 1500 mg, or 2000 mg of the extract.