US2022090006A1PendingUtilityA1

Augmented biocontainment materials and augmented biocontainment enclosures

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Assignee: SECANT GROUP LLCPriority: Jan 17, 2018Filed: Nov 30, 2021Published: Mar 24, 2022
Est. expiryJan 17, 2038(~11.5 yrs left)· nominal 20-yr term from priority
Inventors:Peter D. GabrieleJeremy J. HarrisCharles Brendan NicholsonSteven LuJeffrey H. RobertsonGael Peron
C12M 23/14C12N 2533/30C12M 41/46C12M 23/28C12N 5/0068C12M 23/20C12M 23/52C12M 23/26C12M 25/14
68
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Claims

Abstract

A biocontainment vessel includes a vessel structure including a structural composition and an enhancement composition associated with the structural composition. The enhancement composition includes a co-polymer. The co-polymer is a poly(glycerol sebacate) or a poly(glycerol sebacate urethane). The enhancement composition may also include an augmentation agent associated with the co-polymer. The enhancement composition is located with respect to the structural composition such that the enhancement composition benefits biological cells contained in the biocontainment vessel. A composition includes a co-polymer and an augmentation agent contained by the co-polymer. A method of containing biological cells includes placing the biological cells in an augmented biocontainment vessel and storing them in the augmented biocontainment vessel under predetermined conditions. An augmented substrate includes a substrate and an enhancement composition coating a surface of the substrate.

Claims

exact text as granted — not AI-modified
1 . A filtration system comprising a plurality of fibers coated with a coating comprising a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane) and an augmentation agent associated with the co-polymer. 
     
     
         2 . The filtration system of  claim 1 , wherein the co-polymer is poly(glycerol sebacate). 
     
     
         3 . The filtration system of  claim 1 , wherein the co-polymer is poly(glycerol sebacate urethane). 
     
     
         4 . The filtration system of  claim 1 , wherein the augmentation agent is physically mixed with the co-polymer. 
     
     
         5 . The filtration system of  claim 1 , wherein the augmentation agent is chemically attached to the co-polymer. 
     
     
         6 . The filtration system of  claim 1 , wherein the coating is an affinity coating for toxins. 
     
     
         7 . The filtration system of  claim 1 , wherein the coating is an affinity coating for biologics separation, biologics harvest, or biologics neutralization. 
     
     
         8 . The filtration system of  claim 1 , wherein the coating is a buffer coating. 
     
     
         9 . The filtration system of  claim 1 , wherein the coating protects against hemoglobin scavenging of nitrous oxide. 
     
     
         10 . The filtration system of  claim 1 , wherein the augmentation agent comprises a nutrient. 
     
     
         11 . A method comprising coating a plurality of fibers of a filtration system with a coating comprising a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane) and an augmentation agent associated with the co-polymer. 
     
     
         12 . The method of  claim 11 , wherein the co-polymer is poly(glycerol sebacate). 
     
     
         13 . The method of  claim 11 , wherein the co-polymer is poly(glycerol sebacate urethane). 
     
     
         14 . The method of  claim 11  further comprising physically mixing the augmentation agent with the co-polymer to form the coating. 
     
     
         15 . The method of  claim 11  further comprising chemically attaching the augmentation agent to the co-polymer. 
     
     
         16 . A composition comprising a plurality of fibers coated with a coating comprising a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane) and an augmentation agent associated with the co-polymer. 
     
     
         17 . The coating of  claim 16 , wherein the co-polymer is poly(glycerol sebacate). 
     
     
         18 . The coating of  claim 16 , wherein the co-polymer is poly(glycerol sebacate urethane). 
     
     
         19 . The coating of  claim 16 , wherein the augmentation agent is physically mixed with the co-polymer. 
     
     
         20 . The coating of  claim 16 , wherein the augmentation agent is chemically attached to the co-polymer.

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