Antiviral agents

Abstract

A compound of Formula (I) below, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof: in which R 1 -R 7 , and W are defined as in the SUMMARY section. Further disclosed are a method of using the above-described compound, salt, stereoisomer, enantiomer, solvate, or prodrug for treating or preventing viral infectious diseases and a pharmaceutical composition containing same.

What is claimed is: 
     
         1 . A compound of Formula (I) below, or a pharmaceutically acceptable salt, stereoisomer, enantiomer, solvate, or prodrug thereof, cm  2 . 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 3-12  carbocyclyl, C 3-12  heterocyclyl, aryl, or C 5-10  heteroaryl, wherein said C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 3-12  carbocyclyl, C 3-12  heterocyclyl, aryl, and C 5-10  heteroaryl is each independently optionally substituted with 1 to 4 substituents each independently selected from hydrogen, halogen, NH 2 , OH, CN, C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  haloalkoxy, C 3-6  carbocyclyl, C 3-6  heterocyclyl, aryl, and C 5-6  heteroaryl; 
 W is a bond, C 1-6  alkyl, or C 2-6  alkenyl; 
 R 2  is hydrogen, C 1-6  alkyl, or C 1-6  haloalkyl; 
 R 3  is hydrogen, halogen, CN, C 1-6  alkyl or C 1-6  haloalkyl; 
 R 4  is hydrogen, halogen, CN, C 1-6  alkyl or C 1-6  haloalkyl; 
 R 5  is C 1-6  alkyl optionally substituted with 1 to 3 deuteriums; 
 R 6  is hydrogen, C 1-6  alkyl, or C 1-6  haloalkyl; 
 R 7  is C 3-12  heterocyclyl, aryl, C 5-10  heteroaryl, C 1-6  alkyl-C 3-12  heterocyclyl, C 1-6  alkyl-aryl, or C 1-6  alkyl-C 5-10  heteroaryl wherein said C 3-12  heterocyclyl, aryl, C 5  heteroaryl, C 1-6  alkyl-C 3-12  heterocyclyl, C 1-6  alkyl-aryl, or C 1-6  alkyl-C 5-10  heteroaryl is each independently optionally substituted with one or more substituents each independently selected from hydrogen, halogen, OH, CN, C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 3-12  heterocyclyl, phosphate ester, C 1-6  alkyl-R 8 , C 2-6  alkenyl-R 8 , C 1-6  alkoxy-R 8 , —NHS(O) 2 —R 8 , —S(O) 2 —N(R 8 ) 2 , —NHS(O) 2 —N(R 8 ) 2 , NH—C(═O)—N(R 8 ) 2 , —C(═O)—C(═O)—R 8 , NH—C(═O)—C(═O)—R 8 , —C(═O)—C(═O)—N(R 8 ) 2 , or NH—C(═O)—C(═O)—N(R 8 ) 2 , wherein said C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 3-12  heterocyclyl, phosphate ester, C 1-6  alkyl-R 8 , C 2-6  alkenyl-R 8 , C 1-6  alkoxy-R 8 , —NHS(O) 2 —R 8 , —S(O) 2 —N(R 8 ) 2 , —NHS(O) 2 —N(R 8 ) 2 , NH—C(═O)—N(R 8 ) 2 , —C(═O)—C(═O)—R 8 , NH—C(═O)—C(═O)—R 8 , —C(═O)—C(═O)—N(R 8 ) 2 , or NH—C(═O)—C(═O)—N(R 8 ) 2  is each independently optionally substituted with one or more substituents each independently selected from hydrogen, halogen, OH, CN, oxo, C 1-6  alkyl, or C 1-6  haloalkyl; 
 R 8  is hydrogen, halogen, OH, CN, C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 3-12  carbocyclyl, C 3-12  heterocyclyl, aryl, or C 5-14  heteroaryl, wherein said C 1-6  alkyl, C 2-6  alkenyl, C 1-6  alkoxy, C 3-12  carbocyclyl, C 3-12  heterocyclyl, aryl, or C 5-14  heteroaryl is each independently optionally substituted with one or more halogen, OH, CN, C 1-6  alkyl, C 2-6  alkenyl, C 1-6  haloalkyl, or C 1-6  alkoxy.