Chemical compositions and methods for enhancing transdermal delivery of therapeutic agents

Abstract

The present application discloses chemical compositions and methods for enhancing the transdermal permeation of therapeutic agents through skin. The chemical compositions and methods of the invention can include combinations of a first fatty acid having about 14 or more carbon atoms and a second fatty acid having about 10 or less carbon atoms. These compositions are useful for the delivery of therapeutic agents, in particular hard to deliver drugs such as those that have fused rings, including ondansetron, and large drugs such as peptides. The compositions of the invention can be formulated as transdermal gels, lotions, creams, transdermal patches, sprays or mists.

What is claimed is: 
     
         1 . A composition comprising an anti-coagulant, oleic acid, and levulinic acid. 
     
     
         2 . The composition of  claim 1 , comprising about 0.1% to about 30%, by weight of the composition, of the oleic acid. 
     
     
         3 . The composition of  claim 1 , comprising about 2.5% to about 7.5%, by weight of the composition, of the oleic acid. 
     
     
         4 . The composition of  claim 1 , comprising about 1% to about 5%, by weight of the composition, of the oleic acid. 
     
     
         5 . The composition of  claim 1 , comprising about 0.1% to about 30%, by weight of the composition, of the levulinic acid. 
     
     
         6 . The composition of  claim 1 , comprising about 1% to about 5%, by weight of the composition, of the levulinic acid. 
     
     
         7 . The composition of  claim 1 , comprising about 0.5% to about 2.5%, by weight of the composition, of the levulinic acid. 
     
     
         8 . The composition of  claim 1 , that is for use on human skin. 
     
     
         9 . A transdermal patch comprising a composition comprising an anti-coagulant, oleic acid, and levulinic acid. 
     
     
         10 . The transdermal patch of  claim 9 , comprising about 0.1% to about 30%, by weight of the composition, of the oleic acid. 
     
     
         11 . The transdermal patch of  claim 9 , comprising about 2.5% to about 7.5%, by weight of the composition, of the oleic acid. 
     
     
         12 . The transdermal patch of  claim 9 , comprising about 1% to about 5%, by weight of the composition, of the oleic acid. 
     
     
         13 . The transdermal patch of  claim 9 , comprising about 0.1% to about 30%, by weight of the composition, of the levulinic acid. 
     
     
         14 . The transdermal patch of  claim 9 , comprising about 1% to about 5%, by weight of the composition, of the levulinic acid. 
     
     
         15 . The transdermal patch of  claim 9 , comprising about 0.5% to about 2.5%, by weight of the composition, of the levulinic acid. 
     
     
         16 . The transdermal patch of  claim 9 , that is for use on human skin.