Prosthetic disorder response systems

Abstract

A fully implanted automatic disorder response system is devised to act as a backup “immune” system, automatically detecting and dispensing an enzyme, for example, deficient due to an inborn error of metabolism. In response to a disease, the agent released is one or more drugs. By directly pipeline-targeting agents through a closed system of drug reservoirs, fluid and electrical lines, and leak-free, durable, and safe tissue connectors to the site of disease, the system achieves a level of efficiency critically superior to the systemic dispersal of an agent into the circulation, fundamentally liberalizing the use of drugs. In comorbid disease, each morbidity is assigned to an arm or channel in a hierarchical control system. Beginning with symptomatic indicia sensors, data is analyzed and passed up through successively higher-level nodes that generate a cross-morbidity view passed up to an implanted microprocessor which effectuates a release of drugs calculated to optimize homeostasis.

1 . The combination of a closed system of implanted pipelines for directly pipe-targeting though secure end-connectors to target tissue, and an automatic control system which includes sensors to detect the need for therapy at each site which uses said closed system of pipelines to directly deliver medication respecitive of each site targeted and other forms of therapy such as electrostimulation as appropriate. 
     
     
         2 . An implanted automatic control system according to  claim 1 , which includes sensors to detect analytes associated with disease processes and commands the delivery to the site of the disease process of therapy, usually pharmaceutical, determined by the control system to be optimal for each the disease process. 
     
     
         3 . A system according to  claim 1 , wherein said automatic control system is organized hierarchically, so that the system is able to evaluate sensory data pertaining to each disease process, and by adding sensors for comorbid disease processes, progressively refer this data to higher level controllers able to coordinate the sum of this data and optimize therapy, usually pharmaceutical, for each of the disease processes detected as well as for the disease processes collectively, said system then commanding the directly targeted pipeline delivery to each disease to best affect each as well as the best combination of drugs and other targeted therapy to most closely approximate normal homeostasis across the combination of disease processes. 
     
     
         4 . A primarily implanted automatic disorder response system that coordinates the data provided by a plurality of implanted sensors directed to a disease process and transmits its data to a microcontroller to determine the drug most efficacious therefor and controls the outlet motor of drug reservoir storing that drug to release the drug through a catheteric pipeline that isolates the drug from untargeted tissue directly into the blood supply of the affected tissue targeted. 
     
     
         5 . A primarily implanted automatic disorder response system that coordinates the data provided by a plurality of implanted sensors directed toward one in a plurality of disease processes, these sensors transmitting their data to a microcontroller respective of the disease process aimed at by this set of sensors, other sets of sensors concurrently aimed at other disease processes likewise transmitting their data to microcontrollers respective of the disease process to which each set of sensors is aimed, the data then transmitted to microcontrollers at the level above said sets of sensors to integrate the data sets in order to determine which fewest number of drugs in the smallest doses will optimally affect the combination of disease processes, these microcontrollers then transmitting the results of their integration of the sensory data to a controller at the highest level, that of the master controller, which then controls the outlet motors of the drug reservoirs to release the drugs identified thus through catheteric pipelines to the sites of disease in the relative proportions that should exert the optimally efficacious affect on the combination of disease processes. 
     
     
         6 . Pursuant to the automatic disorder response system according to  claim 1 , a plurality of ductus side-entry jackets and nonjackeing connectors wherewith at least one pump supplying fluid medicinals to said collars is controlled according to a prescription program by a microcontroller, such that:
 a plurality of physiological parameter sensors implanted at different locations in the body send outputs as subordinate negative feedback loop nodes in a hierarchical control system to said microcontroller as master node;   these outputs represent feedback where each signals to the microcontroller an out of range condition that necessitates the prescribed medication;
 the microcontroller responds by causing said pump to index to and release the medication prescribed for that subordinate node in the dose proportional to the out of range feedback signal received; 
   as master node, the microcontroller governs the discharge of the prescription program to include dispensing the medication through each subsidiary control loop as a subordinate node in a coordinated manner as governed by the prescription program so that dosing among the nodes is interrelated to achieve the optimal overall result on health;   such a system overall thus able to treat comorbid conditions affecting different organ systems in a coordinated manner as an automatic homeostasis stabilizer and ambulatory prosthetic disorder response system.