Compositions and methods for treating an infection

Abstract

The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For example, disclosed herein are compounded compositions and methods of making compounded compositions comprising one or more anti-infective agents such as streptomycin and one or more of colistimethate, clindamycin, or mupirocin.

What is claimed is: 
     
         1 . A method of treating or preventing a bacterial infection of a subject, the method comprising:
 formulating a treatment composition comprising combining
 a diluent, 
 a dry powder comprising at least streptomycin, 
 and one or more addition anit-infectives selected from colistimethate, clindamycin, mupirocin, and combination thereof; and 
   contacting a body surface of a subject that is infected or suspected to be infected with the treatment composition to topically deliver the one or more anti-infective agents to the body surface.   
     
     
         2 . The method of  claim 1 , wherein formulating the treatment composition further comprises opening a capsule comprising at least the streptomycin to release the dry powder for combining with the diluent. 
     
     
         3 . The method of  claim 2 , wherein the dry powder further xylitol and poloxamers. 
     
     
         4 . The method of  claim 2 , wherein the dry powder contained in the capsule also contains one or more of the one or more additional anti-infective agents. 
     
     
         5 . The method of  claim 4 , wherein the dry powder further xylitol and poloxamers. 
     
     
         6 . The method of  claim 1 , wherein the compounded composition comprises between about 1% and about 10% streptomycin by weight. 
     
     
         7 . The method of  claim 1 , wherein the contacting the body surface comprises contacting the body surface with a suitable amount of the treatment composition to topically deliver between 25 mg and 1 gm of streptomycin per day. 
     
     
         8 . The method of  claim 1 , wherein the one or more additional anti-infective agents are combined at a ratio between about 1:3 and about 1:10 by weight with respect to the streptomycin. 
     
     
         9 . The method of  claim 8 , wherein the diluent comprises a cream, ointment, emulsion, or gel. 
     
     
         10 . The method of  claim 9 , wherein the diluent comprises a sterile aqueous solution, and contacting the body surface comprises nebulizing the treatment composition to deliver the streptomycin and one or more additional anti-infectives to a surface of a lung of the subject. 
     
     
         11 . The method of  claim 1 , wherein the one or more additional anti-infective agents comprise mupirocin, and formulating the treatment composition comprises combining the streptomycin with mupirocin ointment. 
     
     
         12 . A homogenous compounded ointment for the treatment or prevention of a bacterial infection of a subject treatment, the compounded ointment comprising:
 streptomycin sulfate for injection and one or more additional anti-infective agents selected from colistimethate, clindamycin, mupirocin, and combinations thereof in an ointment base, wherein the compounded ointment comprises between about 1% and 10% streptomycin by weight.   
     
     
         13 . The compounded ointment of  claim 12 , wherein the additional anti-infective agent is present in the compounded ointment at a weight ratio between about 1:3 and about 1:10 by weight with respect to streptomycin of the streptomycin sulfate.