Solid state forms of valbenazine

Abstract

Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described.

1 - 44 . (canceled) 
     
     
         45 . Solid state form of Valbenazine sulfate designated as Form HS1, characterized by data selected from one or more of the following:
 (a) a XRPD pattern having peaks at 6.8, 8.9, 12.6, 15.1 and 21.6 degrees 2-theta 0.2 degrees 2-theta;   (b) a XRPD pattern as depicted in  FIG. 20 ;   (c) or combinations of these data.   
     
     
         46 . The solid state form of Valbenazine sulfate according to  claim 45 , characterized by a XRPD pattern having peaks at 6.8, 8.9, 12.6, 15.1 and 21.6 degrees 2-theta±0.2 degrees 2-theta, and also having one, two, three, four or five additional peaks selected from 17.8, 20.8, 22.9, 20.0 and 22.4 degrees 2-theta±0.2 degrees 2-theta. 
     
     
         47 . A process for preparing a pharmaceutical composition and/or formulation comprising combining the solid state form of Valbenazine sulfate according to  claim 45  with at least one pharmaceutically acceptable excipient. 
     
     
         48 . A pharmaceutical composition or formulation comprising the solid state form of Valbenazine sulfate according to  claim 45 . 
     
     
         49 . A pharmaceutical composition or formulation according to  claim 48  comprising at least one pharmaceutically acceptable excipient, wherein the pharmaceutical composition or formulation is for oral administration.