Biocompatible fiber textiles for implantation

Abstract

A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.

1 - 12 . (canceled) 
     
     
         13 . A biocompatible textile comprising:
 at least one electrospun fiber, comprising at least one polymer, wherein:
 the electrospun fiber forms a plurality of windings formed by electrospinning the at least one polymer on to a mandrel, 
 each winding of the plurality of windings forms an opening with an adjacent winding, thereby forming a plurality of openings between a plurality of adjacent windings, and 
 the plurality of openings comprises a mesh size 1 opening per mm to 20 openings per mm. 
   
     
     
         14 . The biocompatible textile of  claim 13 , wherein the at least one electrospun fiber is disposed on a mandrel. 
     
     
         15 . The biocompatible textile of  claim 14 , wherein the mandrel takes the form of a cylinder, a hollow bodily tissue, or an organ. 
     
     
         16 . The biocompatible textile of  claim 15 , wherein the organ is selected from the group consisting of a trachea, a trachea and at least a portion of at least one bronchus, a trachea and at least a portion of a larynx, a larynx, an esophagus, a large intestine, a small intestine, an upper bowel, a lower bowel, a vascular structure, and portions thereof. 
     
     
         17 . The biocompatible textile of  claim 13 , wherein the at least one polymer comprises polyethylene terephthalate, polyester, polymethylmethacrylate, polyacrylonitrile, silicone, polyurethane, polycarbonate, polyether ketone ketone, polyether ether ketone, polyether imide, polyamide, polystyrene, polyether sulfone, polysulfone, polycaprolactone, polylactic acid, polyglycolic acid, polyglycerol sebacic, polydiol citrate, polyhydroxy butyrate, polyether amide, polydiaxanone, fibronectin, collagen, gelatin, hyaluronic acid, chitosan, or combinations or derivatives thereof. 
     
     
         18 . The biocompatible textile of  claim 13 , wherein the at least one polymeric electrospun fiber comprises an at least one surface-treated polymeric electrospun fiber. 
     
     
         19 . The biocompatible textile of  claim 13 , wherein the plurality of windings forms a plurality of circumferential layers. 
     
     
         20 . The biocompatible textile of  claim 19 , further comprising at least one curved polymer support in mechanical communication with at least one of the plurality of circumferential layers. 
     
     
         21 . The biocompatible textile of  claim 20 , wherein the at least one curved polymer support is a U-shaped support. 
     
     
         22 . A method for fabricating a biocompatible textile comprising:
 electrospinning at least one polymer into an electrospun fiber;   contacting the electrospun fiber with a particulate material having a solubility in a solvent;   contacting the electrospun fiber with a mandrel, thereby forming a plurality of windings, wherein each winding of the plurality of windings forms an opening with an adjacent winding, thereby forming a plurality of openings between a plurality of adjacent windings;   removing the polymer network from the mandrel; and   dissolving the particulate material with the solvent that may not otherwise dissolve the electrospun fibers, thereby forming a biocompatible textile having a mesh size of 1 opening per mm to 20 openings per mm.   
     
     
         23 . The method of  claim 22 , wherein the mandrel takes the form of a cylinder, a hollow bodily tissue, or an organ. 
     
     
         24 . The method of  claim 23 , wherein the organ is selected from the group consisting of a trachea, a trachea and at least a portion of at least one bronchus, a trachea and at least a portion of a larynx, a larynx, an esophagus, a large intestine, a small intestine, an upper bowel, a lower bowel, a vascular structure, and portions thereof. 
     
     
         25 . The method of  claim 22 , wherein the particulate material is a water soluble salt, a water soluble sugar, a water soluble hydrogel, or any combination thereof. 
     
     
         26 . The method of  claim 22 , further comprising treating the electrospun fiber with a treatment selected from the group consisting of washing in a solvent, drying with a gas stream, sterilizing, sintering, and treating with a plasma discharge. 
     
     
         27 . The method of  claim 22 , wherein the plurality of windings forms a plurality of layers.