Textured surfaces for implants

Abstract

An implant material having an implant surface comprising a plurality of tissue-contacting members arranged in a regular or irregular two-dimensional array, each tissue-contacting member having a convex curved tissue-contacting surface. Methods of preparing and using such implant materials.

1 - 21 . (canceled) 
     
     
         22 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface with a biomimetic topography comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 5 μm to 150 μm. 
     
     
         23 . The implant of  claim 22 , wherein the mean average height value of the plurality of tissue-contacting members is in the range of 15 μm to 90 μm. 
     
     
         24 . The implant of  claim 22 , wherein the implant is a breast implant. 
     
     
         25 . The implant of  claim 22 , wherein the tissue-contacting members are hemispherical in shape. 
     
     
         26 . The implant of  claim 22 , wherein the height of at least 30% of the population of the tissue-contacting members fall within a range of 15 μm to 90 μm. 
     
     
         27 . The implant of  claim 22 , wherein the mean average diameter of the plurality of tissue-contacting members is in the range of 1 μm to 120 μm. 
     
     
         28 . The implant of  claim 22 , wherein the implant surface has at least 500 tissue-contacting members per cm 2 . 
     
     
         29 . The implant of  claim 22 , wherein the tissue-contacting surfaces of the plurality of tissue-contacting members comprise nano-scale features having a height in the range of 200 nm to 800 nm. 
     
     
         30 . The implant of  claim 22 , wherein the plurality of tissue-contacting members cover at least 20% of the implant surface. 
     
     
         31 . The implant of  claim 22 , wherein each tissue-contacting member has at least four neighboring tissue-contacting members. 
     
     
         32 . The implant of  claim 22 , wherein the tissue-contacting members are discrete members spaced from each other, or members that are merged or fused together. 
     
     
         33 . The implant of  claim 22 , wherein the implant surface is a closed surface substantially free of pores or other open structures. 
     
     
         34 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 15 μm to 90 μm, and wherein the implant surface is a closed surface substantially free of pores or other open structures. 
     
     
         35 . The implant of  claim 34 , wherein the implant is a breast implant. 
     
     
         36 . The implant of  claim 34 , wherein the implant surface has at least 500 tissue-contacting members per cm 2 . 
     
     
         37 . The implant of  claim 34 , wherein each tissue-contacting member has at least four neighboring tissue-contacting members within a distance of 2× the width of the tissue-contacting member. 
     
     
         38 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface with a biomimetic topography comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 5 μm to 150 μm and the mean average diameter of the plurality of tissue-contacting members is from 1 μm to 120 μm, and wherein implant surface comprises an organosilicon polymer. 
     
     
         39 . The implant of  claim 38 , wherein the implant surface has 1000 to 50000 tissue-contacting members per cm 2 . 
     
     
         40 . The implant of  claim 38 , wherein the implant is a breast implant. 
     
     
         41 . The implant of  claim 38 , wherein the plurality of tissue-contacting members is a plurality of truncated hemispheres arranged to form a two-dimensional array of fused hemispheres.