Terpene based therapeutic deep eutectic system, method of obtaining and uses thereof

Abstract

The present disclosure describes a eutectic composition for use in the treatment of cancer comprising a nonsteroidal anti-inflammatory drug and a terpene, preferably ibuprofen and limonene.

1 . A eutectic composition for use in the treatment or therapy of cancer, the composition comprising a nonsteroidal anti-inflammatory drug and a terpene. 
     
     
         2 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug is selected from the group consisting of: ibuprofen, flurbiprofen, ketoprofen, acetylsalicylic acid, and mixtures thereof. 
     
     
         3 . The composition of  claim 2 , wherein the molar ratio of anti-inflammatory drug:terpene ranges from 1:1-1:8. 
     
     
         4 . The composition of  claim 1 , wherein the molar ratio of anti-inflammatory drug:terpene ranges from 1:3-1:6. 
     
     
         5 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug is ibuprofen and wherein the molar ratio of ibuprofen:terpene ranges from 1:4-1:6. 
     
     
         6 . The composition of  claim 1 , wherein the terpene is limonene and the molar ratio of anti-inflammatory drug:limonene ranges from 1:4-1:6. 
     
     
         7 . The composition of  claim 1 , wherein the terpene is selected from the group consisting of: limonene, carvacrol, thymol, safranal, linalool, myrcene, perilyl alcohol, borneol, geraniol, pinene, citronellol, and mixtures thereof. 
     
     
         8 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug and the terpene comprise the combination of:
 ibuprofen and limonene; ibuprofen and menthol; ibuprofen and carvacrol; ibuprofen and thymol; ibuprofen and safranal; ibuprofen and linalool; ibuprofen and myrcene; ibuprofen and perilyl alcohol; ibuprofen and borneol; ibuprofen and geraniol; ibuprofen and pinene; ibuprofen and citronellol; flurbiprofen and limonene; flurbiprofen and carvacrol; flurbiprofen and thymol; flurbiprofen and safranal; flurbiprofen and linalool; flurbiprofen and perilyl alcohol; flurbiprofen and geraniol; flurbiprofen and citronellol; ketoprofen and carvacrol; ketoprofen and thymol; ketoprofen and safranal; ketoprofen and linalool; ketoprofen and perilyl alcohol; ketoprofen and geraniol; ketoprofen and citronellol; acetylsalicylic acid and safranal; acetylsalicylic acid and linalool; acetylsalicylic acid and geraniol; acetylsalicylic acid and citronellol; or mixtures thereof.   
     
     
         9 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug and the terpene comprising ibuprofen and limonene, respectively, or ibuprofen and perylil alcohol, respectively. 
     
     
         10 . The composition of  claim 9 , wherein the nonsteroidal anti-inflammatory drug and the terpene are ibuprofen and limonene, respectively and wherein the molar ratio of ibuprofen:limonene ranges from 1:3-1:8. 
     
     
         11 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug and the terpene are ibuprofen and limonene, respectively and wherein the molar ratio of ibuprofen:limonene ranges from 1:4-1:6. 
     
     
         12 . The composition of  claim 1 , wherein the nonsteroidal anti-inflammatory drug is ibuprofen and wherein the ibuprofen concentration is 0.25-0.5 mM. 
     
     
         13 . The composition of  claim 1 , wherein the terpene is limonene and wherein the limonene concentration is 1-2 mM. 
     
     
         14 . The composition of  claim 1 , wherein the composition is an injectable composition or an oral composition. 
     
     
         15 . The composition of  claim 1 , wherein the composition is suitable for use as an anti-proliferator of cancer cells. 
     
     
         16 . A method of inhibiting the proliferation of cancer cells in a subject, the method comprising administering the composition of  claim 1  to the subject.