Wound sealing powder

Abstract

A wound sealing powder, method of making a wound sealing powder, and method of using a wound sealing powder to reduce blood flow from a wound are provided. Specifically, the wound sealing powder utilizes a particulate powder material of an effective amount of an insoluble cation exchange material wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns.

What is claimed is: 
     
         1 . A wound sealing composition comprising a particulate powder consisting essentially of a mixture of a substantially anhydrous salt ferrate compound and an effective amount of an insoluble cation exchange material, wherein the powder contains essentially no particles having a particle size of 158 microns or more. 
     
     
         2 . The wound sealing composition of  claim 1 , wherein the powder contains essentially no particles having a particle size of 98 microns or more. 
     
     
         3 . The wound sealing composition of  claim 1 , wherein the powder contains essentially no particles having a particle size of 77 microns or more. 
     
     
         4 . A method of making a particulate powder for a wound sealing composition wherein the powder consists essentially of a substantially anhydrous salt ferrate compound combined with an effective amount of an insoluble cation exchange material wherein the powder contains essentially no particles having a particle size of 158 microns or more, the method comprising steps of:
 a) drying an insoluble cation exchange material to a moisture content of approximately 3% or less;   b) mixing a substantially anhydrous salt ferrate compound having an average particle size of 2 mm or less with the cation exchange material at a weight ratio of approximately 1 to 2, ferrate to cation exchange material;   c) providing the dried cation exchange material at an average particle size of less than about 70 microns; and   d) blending the mixed 1:2 ferrate:cation exchange material with the dried cation exchange material having an average particle size of less than about 70 microns to obtain an approximate 1 to 7 weight mixture of ferrate to cation exchange material.   
     
     
         5 . The method of  claim 4  wherein the dried cation exchange material at an average particle size of less than about 70 microns is provided by grinding whole or reduced-size beads of the cation exchange material. 
     
     
         6 . The method of  claim 5  where the grinding is performed utilizing a stirred ball mill. 
     
     
         7 . A method of arresting or reducing the blood flow from a wound on a patient having a blood-letting wound comprising the steps of applying a wound sealing composition comprising a particulate powder consisting essentially of a substantially anhydrous salt ferrate compound combined with an effective amount of an insoluble cation exchange material wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns and allowing a seal to form over the wound so that blood flow from the wound is reduced. 
     
     
         8 . A wound sealing composition comprising a particulate powder consisting essentially of a ground insoluble cation exchange material, wherein at least 90% of the particles in the powder have a particle size of 77 microns or less and wherein no more than 10%, by weight, of the particles in the particulate powder are unground particles of the insoluble cation exchange material. 
     
     
         9 . The wound sealing composition of  claim 8  wherein no more than 5%, by weight, of the particles in the particulate powder are unground particles of the insoluble cation exchange material. 
     
     
         10 . A wound sealing composition comprising a particulate powder consisting essentially of a ground insoluble cation exchange material, wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns and wherein no more than a minority of the particles in the particulate powder are unground particles of the insoluble cation exchange material. 
     
     
         11 . The wound sealing composition of  claim 10  wherein no more than 5%, by weight, of the particles in the particulate powder are unground particles of the insoluble cation exchange material. 
     
     
         12 . The wound sealing composition of  claim 1 ,  8 , or  10  further comprising a pigment. 
     
     
         13 . The wound sealing composition of  claim 1 ,  8 , or  10  further comprising an antimicrobial. 
     
     
         14 . The wound sealing composition of  claim 1 ,  8 , or  10  further comprising a multivalent hemostatic salt. 
     
     
         15 . A wound sealing composition comprising a particulate powder consisting essentially of an insoluble cation exchange material, wherein at least 90%, by weight, of the particles in the powder have a particle size of 77.4 microns or less and the moisture content of the powder is 20% or less. 
     
     
         16 . The wound sealing composition of  claim 15  wherein the moisture content of the powder is 3% or less. 
     
     
         17 . The wound sealing composition of  claim 15  wherein the moisture content of the powder is approximately 1%. 
     
     
         18 . A wound sealing composition comprising a particulate powder consisting essentially of a ground insoluble cation exchange material wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns and the moisture content of the powder is 20% or less. 
     
     
         19 . The wound sealing composition of  claim 18  wherein the moisture content of the powder is 3% or less. 
     
     
         20 . The wound sealing composition of  claim 18  wherein the moisture content of the powder is approximately 1%. 
     
     
         21 . A compressed tablet comprising the wound sealing composition of  claim 1 ,  8 ,  9 ,  10 ,  11 ,  15 ,  18 , or  19 .