Compositions and methods for cancer therapy

Abstract

The invention provides compositions and methods to treat relapsed multiple myeloma with pharmacological ascorbic acid or a pharmaceutically acceptable salt thereof, and one or more anti-cancer therapies.

What is claimed is: 
     
         1 . A method of treating a hyperproliferative disorder associated with high intracellular iron comprising administering pharmacological ascorbic acid or a pharmaceutically acceptable salt thereof and melphalan, wherein the pharmacological ascorbic acid is administered at a dose of about 15 g-100 g, wherein the hyperproliferative disorder is relapsed multiple myeloma. 
     
     
         2 . The method of  claim 1 , wherein the melphalan is administered at a dosage of about 2 mg/m 2  to 200 mg/m 2 . 
     
     
         3 . The method of  claim 1 , wherein the melphalan is administered at a dosage of about 50 mg/m 2  and 100 mg/m 2 . 
     
     
         4 . The method of  claim 1 , wherein the pharmacological ascorbic acid and the melphalan are administered simultaneously or sequentially. 
     
     
         5 . The method of  claim 1 , further comprising administering a proteasome inhibitor. 
     
     
         6 . The method of  claim 5 , wherein the pharmacological ascorbic acid, the melphalan and the proteasome inhibitor are administered simultaneously or sequentially in any order. 
     
     
         7 . The method of  claim 1 , further comprising administering an anti-cancer therapy. 
     
     
         8 . The method of  claim 7 , wherein the anti-cancer therapy is immunotherapy or biologic therapy.