Methods of treatment and pharmaceutical compositions using bcn057 or bcn512

Abstract

The present disclosure is directed to method of treatment for treating or ameliorating various conditions pertaining such as bone marrow recovery (or blood cell production), fibrosis, inflammatory diseases, inhibition of cancer cell growth, propagation or malignancy, thrombocytopenia, wound healing, and conditions related to stem cells by the administration of BCN057, 512, or an analog thereof.

What is claimed is: 
     
         1 . A method of increasing hematopoiesis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of BCN057 or an analog thereof. 
       
         
           
           
               
               
           
         
       
     
     
         2 . The method of  claim 1 , wherein the subject has one or more of blood cancer, lymphoma, leukemia, AML, ALL, bone marrow ablation, bone marrow transplant, bone marrow suppression, a platelet disorder, thrombocytopenia, Von Willebrand disease, and clinical radiation and chemotherapy related exposure. 
     
     
         3 . The method of  claim 2 , wherein the platelet disorder is caused by one or more of bone marrow failure, bone marrow suppression, chronic alcohol abuse, congenital macrothrombocytopenias, viral infection, bacterial infection, myelodysplastic syndrome, neoplastic marrow infiltration, a nutritional deficiency, radiation and chemotherapy. 
     
     
         4 . The method of  claim 1 , wherein the analog of BCN057 is selected from the group consisting of Formula IB, Formula IC, Formula ID, Formula IE, Formula IF, Formula IG and Formula IH: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         5 . The method of  claim 1 , wherein the subject received radiation therapy and/or chemotherapy. 
     
     
         6 . The method of  claim 3 , wherein the bone marrow failure is caused by one or more of aplastic anemia, paroxysmal nocturnal hemoglobinuria and Shwachman-Diamond syndrome. 
     
     
         7 . The method of  claim 3 , wherein the bone marrow suppression is caused by one or more of medication, chemotherapy and irradiation. 
     
     
         8 . The method of  claim 3 , wherein the congenital macrothrombocytopenia is one or more of Alport syndrome, Bernard-Soulier syndrome, Fanconi anemia, platelet-type or pseudo-von Willebrand disease and Wiskott-Aldrich syndrome. 
     
     
         9 . The method of  claim 3 , wherein the viral infection is one or more of cytomegalovirus, Epstein-Barr virus, hepatitis C virus, HIV, mumps, parvovirus B19, rickettsia, rubella and varicella-zoster virus. 
     
     
         10 . The method of  claim 3 , wherein the nutritional deficiency is a lack of one or more of vitamin B12 and folate.