Modified release formulations containing drug-ion exchange resin complexes

Abstract

A particulate, modified release barrier coated drug-cation exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. Methods of making and products containing this coated complex are described.

1 . A composition comprising at least one modified release, diffusion barrier coated drug-ion exchange resin complex matrix,
 said matrix comprising a pharmaceutically active drug bound to a pharmaceutically acceptable ion exchange resin, a water insoluble release retardant, and   a coating over said matrix, said coating comprising a cured polyvinyl acetate polymer coating and a plasticizer.   
     
     
         2 . The composition according to  claim 1 , comprising a mixture of uncoated drug resin complex comprising a pharmaceutically active drug bound to an ion exchange resin and the coated drug resin complex according to  claim 1 , which further comprises a water insoluble release retardant in a matrix with the drug-ion exchange resin complex. 
     
     
         3 . The composition according to  claim 1  which is a liquid suspension which comprises a pharmaceutically acceptable suspension base. 
     
     
         4 . The composition according to  claim 1 , wherein the drug is selected from the group consisting of morphine, oxycodone, albuterol, methylphenidate, dextromethorphan, codeine, tramadol, pseudoephedrine, phenylephrine, hydrocodone, venlafaxine, ibuprofen, oxybutynin, metformin, clonidine, dexchlorpheniramine, fexofenadine, diphenhydramine, phylpropranolamine, chlorpheniramine, amphetamine, naproxene, diclofenac, selegiline, paroxetine, amoxicillin and pharmaceutically acceptable salts thereof.