Methods and devices for cellular activation

Abstract

An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

1 . A device for reducing inflammation in a wound comprising a stretchable substrate comprising biocompatible electrodes capable of generating a low level electric field (LLEF) or low level micro current (LLMC). 
     
     
         2 . The device of  claim 1  wherein the biocompatible electrodes comprise a first array comprising a pattern of microcells formed from a first conductive material, and a second array comprising a pattern of microcells formed from a second conductive material. 
     
     
         3 . The device of  claim 2  wherein the first conductive material and the second conductive material comprise the same material. 
     
     
         4 . The device of  claim 3  wherein the first and second array each comprise a discrete circuit. 
     
     
         5 . The device of  claim 4 , further comprising a power source. 
     
     
         6 . The device of  claim 2  wherein the first array and the second array spontaneously generate a LLEF. 
     
     
         7 . The device of  claim 6  wherein the first array and the second array spontaneously generate a LLMC when contacted with an electrolytic solution. 
     
     
         8 . The device of  claim 6  wherein the LLEF is between 0.05 and 5 Volts. 
     
     
         9 . The device of  claim 8  wherein the LLEF is between 0.1 and 5 Volts. 
     
     
         10 . The device of  claim 8  wherein the LLEF is between 1.0 and 5 Volts. 
     
     
         11 . The device of  claim 7  wherein the LLMC is between 1 and 200 micro-amperes. 
     
     
         12 . The device of  claim 11  wherein the LLMC is between 1 and 100 micro-amperes. 
     
     
         13 . The device of  claim 11  wherein the LLMC is between 100 and 200 micro-amperes. 
     
     
         14 . The device of  claim 11  wherein the LLMC is between 150 and 200 micro-amperes.