Compositions comprising protocatechuic acid and methods of use

Abstract

This disclosure is directed to methods of using compositions comprising protocatechuic acid (PCA) to kill virus including a Covid-19 virus. The compositions generally comprise protocatechuic acid, a liquid vehicle, and a stabilizer. In embodiments, the liquid vehicle comprises an alcohol and/or water. In preferred embodiments, the oil is an essential oil. In embodiments, the compositions may comprise principally protocatechuic acid, liquid vehicle, and stabilizer as the main ingredients. The compositions may be sprayed onto various products and articles of manufacture, and mammalian and human skin, to kill virus including a Covid-19 virus and to further protect the product or human skin for a period of time up to 24 hours or more. In preferred embodiments, an alcohol component kills virus on contact, and after drying, the residual surface PCA coating provides a continuing anti-viral function.

The claimed invention is: 
     
         1 . A nasal spray product for inactivating a virus comprising:
 a composition comprising protocatechuic acid and water; and   a mechanical nasal sprayer.   
     
     
         2 . The nasal spray product of  claim 1 , wherein the composition further comprises propylene glycol. 
     
     
         3 . The nasal spray product of  claim 1 , wherein the composition further comprises a stabilizer. 
     
     
         4 . The nasal spray product of  claim 1 , wherein the stabilizer comprises sodium benzoate. 
     
     
         5 . The nasal spray product of  claim 1 , wherein the stabilizer comprises glycerin. 
     
     
         6 . The nasal spray product of  claim 1 , wherein the composition comprises protocatechuic acid at a concentration up to 1.24% by weight. 
     
     
         7 . The nasal spray product of  claim 1 , wherein the composition comprises protocatechuic acid at a concentration between 1.24% and 30% by weight. 
     
     
         8 . A method of inactivating a virus with the nasal spray product of  claim 1  comprising:
 spraying, coating, or fogging a composition comprising protocatechuic acid, a liquid vehicle comprising water, and a stabilizer, to mucous membranes of a nose, a mouth, a pharynx, a respiratory tree, or lungs of a mammal. 
 
     
     
         9 . The method of  claim 8 , wherein the composition further comprises propylene glycol. 
     
     
         10 . The method of  claim 8 , wherein the virus is a coronavirus. 
     
     
         11 . The method of  claim 8 , wherein the virus is a SARS-CoV-2 virus. 
     
     
         12 . The method of  claim 8 , wherein the composition further comprises a stabilizer. 
     
     
         13 . The method of  claim 12 , wherein the stabilizer comprises sodium benzoate. 
     
     
         14 . The method of  claim 12 , wherein the stabilizer comprises glycerin. 
     
     
         15 . The method of  claim 8 , wherein the protocatechuic acid comprises protocatechuic acid crystals. 
     
     
         16 . The method of  claim 8 , wherein the protocatechuic acid crystals inactivate the virus in the dry state or in solution. 
     
     
         17 . The method of  claim 8 , wherein the virus is inactivated at 95% or greater. 
     
     
         18 . The method of  claim 8 , wherein the virus is inactivated at 99% or greater. 
     
     
         19 . The method of  claim 8 , wherein the virus is inactivated at 99.9% or greater. 
     
     
         20 . The method of  claim 8 , wherein the composition comprises protocatechuic acid at a concentration up to 1.24%. 
     
     
         21 . The method of  claim 9 , wherein the composition comprises protocatechuic acid at a concentration between 1.24% and 30% by weight.