Self-righting articles

Abstract

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

1 - 34 . (canceled) 
     
     
         35 . A self-righting article, comprising:
 a payload portion configured to comprise an active pharmaceutical ingredient for release internally of a subject that ingests the article,   wherein the self-righting article is a monostatic body due to a center of mass of the self-righting article and/or the shape of the self-righting article, such that the self-righting article has a single stable resting position.   
     
     
         36 . A self-righting article configured for administration to a subject,
 wherein the self-righting article is configured for delivery of an active pharmaceutical ingredient to the subject, and   wherein the self-righting article is a monostatic body due to a center of mass of the self-righting article and/or the shape of the self-righting article, such that the self-righting article has a single stable resting position.