US2022177482A1PendingUtilityA1

Process for the preparation of n-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

62
Assignee: BRISTOL MYERS SQUIBB COPriority: Jul 20, 2017Filed: Feb 22, 2022Published: Jun 9, 2022
Est. expiryJul 20, 2037(~11 yrs left)· nominal 20-yr term from priority
Inventors:Burcu Selin AytarAlina BorovikaCollin ChanJoerg DeerbergNathan R. DomagalskiMartin D. EastgateYu FanMichael David Bengt FensterRobert V. ForestFrancisco Gonzalez-BobesRebecca A. GreenMatthew R. HickeyNathaniel David KoppThomas E. La CruzKathleen LauserHong Geun LeeDavid K. LeahyHelen Y. LuoThomas M. RazlerScott A. SavageChris SfouggatakisMaxime C. SoumeillantSerge ZaretskyBin ZhengYe Zhu
C07C 327/22C07B 2200/07C07D 487/04C07C 271/22A61K 31/53C07C 2601/14C07D 207/273C07D 235/06C07C 269/06A61P 35/00
62
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A compound as shown in the table below; 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Compound No. 
                   Structure 
                 
                     
                     
                 
                     
                 
                 
                 
                 
               
                     
                   3 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   4 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   4a 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   5 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   5a 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   7 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   8 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   9 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   10 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   10a 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   14 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                     
                 
                     
                   14a

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.