Topical dapsone and dapsone/adapalene compositions and methods for use thereof

Abstract

Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin. Use of the polymeric viscosity builder provides compositions with increased concentrations of diethylene glycol monoethyl ether relative to compositions without the polymeric viscosity builder.

1 - 12 . (canceled) 
     
     
         13 . A method of treating acne vulagaris comprising administering to a subject in need thereof a therapeutically effective amount of topical pharmaceutical composition comprising:
 7.5% w/w dapsone;   about 30% w/w diethylene glycol monoethyl ether;   about 4% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer;   0.2% w/w methyl paraben; and water;   wherein the dapsone is the sole active agent for the treatment of acne in the composition.