Magnetic particle conjugates, micelles, and methods of delivering agents

Abstract

Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.

We claim: 
     
         1 . A composition comprising: a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer comprises a plurality of moieties having the following structure: 
       
         
           
           
               
               
           
         
         wherein N in each of the plurality of moieties is bonded to the polymer, wherein the agent includes a drug, a therapeutic agent, a radiological agent, or a biological agent 
       
     
     
         2 . The composition of  claim 1 , wherein further comprising one or more biocompatible moieties. 
     
     
         3 . The composition of  claim 2 , wherein the biocompatible moieties are selected from one or more of the following groups: a PEG group, a poly (N-(2-Hydroxypropyl) methacrylamide) (PHPMA) group, a poly(PEGMA) group, a polyoxazoline group, and a polybetaine group. 
     
     
         4 . The composition of  claim 1 , wherein the polymer is selected from a block copolymer of poly(ethylene glycol), poly(oxazolines), poly(ε-caprolactone), poly(D/L-lactic acid), acrylamide-based monomers, methacrylamide-based monomers, acrylate-based monomers, or methacrylate-based monomers. 
     
     
         5 . A composition comprising: a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer includes an agent (A gent ) bonded to the polymer through thermally degradable group Q, wherein the polymer is represented by the following: 
       
         
           
           
               
               
           
         
       
       where the polymer has one or more Q-A gent  groups, wherein Q is selected from a retro-Diels-Alder-agent group or an azo group. 
     
     
         6 . The composition of  claim 5 , wherein Q is selected from a retro-Diels-Alder-agent group. 
     
     
         7 . The composition of  claim 5 , wherein the polymer is represented by: 
       
         
           
           
               
               
           
         
       
       wherein one of the polymer or agent is optionally linked to the furan group through the 2 or 3 position, wherein the other of the polymer or agent is optionally linked to the N, wherein R is selected from the group consisting of: an alkoxy group (—CH 2 —O—), an alkyl group (—(CH 2 ) n —, and a ester group (—C(O)—O—). 
     
     
         8 . The composition of  claim 7 , wherein the polymer is linked to the furan group through the 2 or 3 position, wherein the agent is linked to the N, wherein R is selected from the group consisting of: an alkoxy group (—CH 2 —O—), an alkyl group (—(CH 2 ) n —, and a ester group (—C(O)—O—). 
     
     
         9 . The composition of  claim 8 , wherein the magnetic particle is a material selected from the group consisting of: Fe 3 O 4 , γFe 2 O 3 , αFe 2 O 3 , MnFe 2 O 4 , ZnFe 2 O 4 , or Mn 0.5 Zn 0.5 Fe 2 O 4 . 
     
     
         10 . The composition of  claim 8 , wherein the agent includes a drug, a therapeutic agent, a radiological agent, or a biological agent. 
     
     
         11 . The composition of  claim 10 , further comprising a targeting agent. 
     
     
         12 . The composition of  claim 8 , wherein the polymer fully encapsulates both the agent and the magnetic particles. 
     
     
         13 . The composition of  claim 7 , wherein one of the agent is linked to the furan group through the 2 or 3 position, wherein the other of the polymer is linked to the N, wherein R is selected from the group consisting of: an alkoxy group (—CH 2 —O—), an alkyl group (—(CH 2 ) n —, and a ester group (—C(O)—O—). 
     
     
         14 . The composition of  claim 13 , wherein the magnetic particle is a material selected from the group consisting of: Fe 3 O 4 , γFe 2 O 3 , αFe 2 O 3 , MnFe 2 O 4 , ZnFe 2 O 4,  or Mn 0.5 Zn 0.5 Fe 2 O 4 . 
     
     
         15 . The composition of  claim 13 , wherein the agent includes a drug, a therapeutic agent, a radiological agent, or a biological agent. 
     
     
         16 . The composition of  claim 15 , further comprising a targeting agent. 
     
     
         17 . The composition of  claim 13 , wherein the polymer fully encapsulates both the agent and the magnetic particles. 
     
     
         18 . The composition of  claim 5 , wherein Q and A are represented by the following structure: 
       
         
           
           
               
               
           
         
         wherein N is bonded to the polymer. 
       
     
     
         19 . The composition of  claim 18 , wherein the polymer fully encapsulates both the agent and the magnetic particles. 
     
     
         20 . The composition of  claim 19 , further comprising a targeting agent.