Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof

Abstract

The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.

What is claimed is: 
     
         1 . The compound according to formula I, or pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A pharmaceutical composition, comprising a therapeutically effective amount of the compound, or pharmaceutically acceptable salts thereof, of  claim 1 , and one or more pharmaceutical excipients. 
     
     
         3 . A method of treating an autoimmune disease in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 1 , and one or more pharmaceutical excipients. 
     
     
         4 . The method of  claims 3 , wherein the subject is a mammal 
     
     
         5 . The method of  claims 4 , wherein the mammal is a human. 
     
     
         6 . The method of  claims 5 , wherein the autoimmune disease is multiple sclerosis. 
     
     
         7 . A method of preventing multiple sclerosis in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 1 , and one or more pharmaceutical excipients. 
     
     
         8 . The method of  claims 7 , wherein the subject is a mammal 
     
     
         9 . The method of  claims 8 , wherein the subject is a mammal 
     
     
         10 . A method of prophylactic of multiple sclerosis in a subject, comprising administering to a human subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 1 , and one or more pharmaceutical excipients. 
     
     
         11 . The compound according to formula II, or pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
         12 . A pharmaceutical composition, comprising a therapeutically effective amount of the compound, or pharmaceutically acceptable salts thereof, of  claim 11 , and one or more pharmaceutical excipients. 
     
     
         13 . A method of treating an autoimmune disease in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 11 , and one or more pharmaceutical excipients. 
     
     
         14 . The method of  claims 13 , wherein the subject is a mammal 
     
     
         15 . The method of  claims 14 , wherein the mammal is a human 
     
     
         16 . The method of  claims 15 , wherein the autoimmune disease is multiple sclerosis. 
     
     
         17 . A method of preventing multiple sclerosis in a subject, comprising administering to the subject in need thereof an effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 11 , and one or more pharmaceutical excipients. 
     
     
         18 . The method of  claims 17 , wherein the subject is a mammal. 
     
     
         19 . The method of  claims 18 , wherein the subject is a mammal 
     
     
         20 . A method of prophylactic of multiple sclerosis in a subject, comprising administering to a human subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, of  claim 11 , and one or more pharmaceutical excipients.