US2022193188A1PendingUtilityA1

Diagnosis, prevention, and/or treatment of autoimmune diseases

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Assignee: IMMUNOWORK LLCPriority: Aug 12, 2016Filed: Mar 7, 2022Published: Jun 23, 2022
Est. expiryAug 12, 2036(~10 yrs left)· nominal 20-yr term from priority
Inventors:Quansheng Zhu
G01N 2500/10G01N 33/6878G01N 33/564A61K 47/64A61K 47/65A61K 38/16A61P 13/12A61K 38/177G01N 33/68G01N 33/96
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Claims

Abstract

Compositions, methods, and kits are for the diagnosis, prevention and/or treatment of autoimmune diseases by detecting, targeting, and/or eliminating epitope-specific autoimmune cells. The compositions include a conjugate of an epitope and an agent that allows for detecting, targeting, and/or eliminating epitope-specific autoimmune cells.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a patient with membranous nephropathy (MN), the method comprising:
 identifying a patient with MN; and   administering to the patient a complex comprising a PLA2R epitope and a drug, wherein the epitope is comprised within a PLA2R fragment,   thereby eliminating or reducing an anti-PLA2R autoantibody producing B cell population in the patient.

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