Dentifrice Composition Comprising Zinc Oxide and Zinc Citrate

Abstract

Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

1 . An oral care composition having synergistic antibacterial effects comprising zinc oxide and zinc citrate
 wherein the weight ratio of zinc oxide:zinc citrate is 2:1, and wherein the amount of zinc oxide is 0.5 to 1.5% and the amount of zinc citrate is 0.25 to 0.75%, by weight of the composition;   wherein the composition comprises sodium fluoride; and   wherein the antibacterial effects are measured as reduction in colony forming units after the composition is applied to incubated hydroxyapatite disks and incubated for 8 days, and wherein the antibacterial effects are measured after said hydroxyapatite disks are collected aseptically and transferred to a half-strength, pre-reduced, thioglycollate medium.   
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . The composition of  claim 1 , wherein the amount of zinc oxide is 1% and the amount of zinc citrate is 0.5% 
     
     
         5 . The composition of  claim 1  further comprising an orally acceptable carrier. 
     
     
         6 . The composition of  claim 1  in the form of a dentifrice. 
     
     
         7 . The composition of  claim 1  in the form of a toothpaste or tooth gel. 
     
     
         8 . The composition of  claim 1 , wherein the composition comprises greater than 15%, by weight, free water. 
     
     
         9 . A method of treating or preventing a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with the composition of  claim 1 . 
     
     
         10 . The method of  claim 9 , wherein the disease or condition of the oral cavity is halitosis. 
     
     
         11 . (canceled) 
     
     
         12 . (canceled)