Method of inducing satiety

Abstract

The invention provides a method of inducing satiety in a subject comprising a step of orally administering a composition comprising an effective amount of a first agent capable of inducing satiety and of a second agent capable of augmenting the satiety-inducing effect of the first agent. Also disclosed are compositions for carrying out the method, and a body weight management system comprising such compositions in combination with a device configured for the collection, storage and/or display of information relating to a subject's response to a predefined therapeutic regimen of orally administering the composition.

1 . An oral composition comprising an effective amount of
 (a) a first agent capable of inducing satiety,   (b) a second agent capable of augmenting the satiety-inducing effect of the first agent,   
       and optionally
 (c) an amino acid, 
 (d) a vitamin, and/or 
 (e) a micro-nutrient. 
 
     
     
         2 . The composition of  claim 1 , wherein the second agent increases the bioavailability of at least the first agent. 
     
     
         3 . The composition of  claim 1 , wherein the second agent prolongs the gastric residence time and/or the small intestinal residence time of at least the first agent. 
     
     
         4 . The composition of  claim 1 , wherein the second agent increases the strength or duration of contact of at least the first agent to the gastrointestinal mucosa. 
     
     
         5 . The composition of  claim 1 , wherein the first agent is a free or esterified medium or long chain fatty acid, wherein the free fatty acid is optionally neutralised. 
     
     
         6 . The composition of  claim 5 , wherein the medium or long chain fatty acid of the first agent has a melting range below 37° C. 
     
     
         7 . The composition of  claim 1 , wherein the second agent is a water-swellable or water-soluble polymeric component. 
     
     
         8 . The composition of  claim 7 , wherein the water-swellable or water-soluble polymeric component comprises at least one polymeric material selected from poly(carboxylate), chitosan, cellulose ethers, and xanthan gum; and
 wherein the poly(carboxylate) is preferably selected from alginic acid, poly(acrylic acid), poly(methacrylic acid), copolymers of acrylic and methacrylic acid, poly(hydroxyethyl methacrylic acid);   wherein the cellulose ether is preferably selected from hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, and carboxymethylcellulose;   wherein the poly(carboxylate) and/or the carboxymethylcellulose is optionally at least partially neutralised; and   wherein the polymeric material is optionally at least partially crosslinked.   
     
     
         9 . A method of inducing satiety in a subject, said method comprising a step of orally administering the composition of  claim 1 . 
     
     
         10 . A method of treating or preventing overweight, obesity, or a disease or condition associated with overweight or obesity in a subject, said method comprising a step of orally administering the composition of  claim 1 . 
     
     
         11 . A method of controlling or reducing the body weight of a subject, said method comprising a step of orally administering the composition of  claim 1 . 
     
     
         12 . The method of  claim 9 , wherein the subject is a human subject having developed, or being at risk of developing, overweight, obesity, or a disease or condition associated with overweight or obesity. 
     
     
         13 . The method of  claim 9 , wherein the oral administration of the composition is performed at least once a day over a period of at least one week. 
     
     
         14 . The method of  claim 9 , further comprising the use of a device for the collection, storage and/or display of information relating to a subject's adherence to, or the effectiveness of, a predefined therapeutic regimen of orally administering the composition. 
     
     
         15 . A body weight management system comprising the composition of  claim 1  and a device configured for the collection, storage and/or display of information relating to a subject's adherence, or the effectiveness of, a predefined therapeutic regimen of orally administering the composition.