Composition for controlled release of therapeutic agents

Abstract

Provided are novel peptides, methods of their preparation and their use in controlled release of pharmaceutically active compounds.

1 - 29 . (canceled) 
     
     
         30 . A controlled release formulation comprising:
 i) a pharmaceutically active compound having a log P value of less than 4; and   ii) a peptide of formula I:
   B-U-W,   I
 
 wherein: 
 each of B and W independently is a peptide comprising at least 75% acidic amino acids or 75% basic amino acids, provided that when B is a peptide having at least 75% acidic amino acids, W is a peptide having at least 75% basic amino acids or vice versa; 
 U is a peptide comprising neutral amino acids; and 
 each of B, U and W independently comprises 2 to 9 amino acids, provided that the peptide of formula I comprises from about 9 to 21 amino acids, 
   
       wherein release of the pharmaceutically active compound is controlled by adjusting weight ratio of the pharmaceutically active compound to the peptide of formula I. 
     
     
         31 . (canceled) 
     
     
         32 . A peptide of formula I:
   B-U-W,   I
   wherein:   each of B and W independently is a peptide comprising at least 75% acidic amino acids or 75% basic amino acids, provided that when B is a peptide having at least 75% acidic amino acids, W is a peptide having at least 75% basic amino acids or vice versa;   U is a peptide comprising neutral amino acids; and   each of B, U and W independently comprises 2 to 9 amino acids, provided that the peptide of formula I comprises from about 9 to 21 amino acids.   
     
     
         33 . The peptide according to  claim 32 , wherein the acidic amino acids are independently selected from aspartic acid or glutamic acid. 
     
     
         34 . The peptide as in  claim 32 , wherein the basic amino acids are independently selected from lysine, arginine or histidine. 
     
     
         35 . The peptide as in  claim 32 , wherein the neutral amino acids are independently selected from tryptophan, phenylalanine, glycine, alanine, valine, isoleucine, leucine, serine, threonine, tyrosine, asparagine, glutamine and proline. 
     
     
         36 . The peptide as in  claim 32 , wherein B comprises at least 75% acidic amino acids and remaining neutral amino acids and W comprises at least 75% basic amino acids and remaining neutral amino acids or vice versa. 
     
     
         37 . The peptide as in  claim 32 , wherein B comprises 100% acidic amino acids and W comprises 100% basic amino acids or vice versa. 
     
     
         38 . The peptide as in  claim 32 , wherein each of B, U and W independently comprises from 3 to 6 amino acids. 
     
     
         39 . The peptide as in  claim 32 , wherein each of B and W comprises equal number of amino acids. 
     
     
         40 . The peptide as in  claim 32 , wherein each of B, U and W comprises equal number of amino acids. 
     
     
         41 - 47 . (canceled)