US2022213020A1PendingUtilityA1
Synthesis of intermediates for producing prostacyclin derivatives
Est. expiryOct 20, 2034(~8.2 yrs left)· nominal 20-yr term from priority
C07C 69/92C07C 45/78C07C 67/333C07C 2603/14C07C 45/67C07C 45/81C07C 67/343C07C 45/64C07C 69/84C07C 67/31C07C 47/565C07C 45/673C07C 47/575
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Claims
Abstract
The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
Claims
exact text as granted — not AI-modified1 - 19 . (canceled)
20 . A batch for a pharmaceutical manufacturing method comprising at least 10 g of a compound of formula 3:
wherein X is hydrogen, an alkoxy group or OR.sup.2, wherein R.sup.2 is unsubstituted or substituted aryl, or unsubstituted or substituted benzyl; wherein purity of the compound of formula 3 is at least 96% by weight of the batch.
21 . The batch of claim 20 , which is produced without column chromatography.
22 . The batch of claim 20 , wherein the purity of the compound of formula 3 is at least 97% by weight of the batch.
23 . The batch of claim 20 , wherein the purity of the compound of formula 3 is at least 98% by weight of the batch.
24 . The batch of claim 20 , wherein the purity of the compound of formula 3 is at least 99% by weight of the batch.
25 . The batch of claim 20 , comprising at least 100 g of a compound of formula 3.
26 . The batch of claim 20 , comprising at least 200 g of a compound of formula 3.
27 . The batch of claim 20 , comprising at least 300 g of a compound of formula 3.Join the waitlist — get patent alerts
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