Embolization devices and methods of manufacturing the same

Abstract

There is provided an embolization device for promoting clot formation in a bodily lumen and having a contracted delivery configuration and an expanded deployed configuration, the embolisation device comprising: a stem comprising a tube having a tube wall; and a plurality of flexible bristles extending radially outwardly from the tube, wherein at least one of the plurality of flexible bristles penetrates through the tube wall.

1 - 86 . (canceled) 
     
     
         87 . An embolization device for promoting clot formation in a bodily lumen and having a contracted delivery configuration and an expanded deployed configuration, the embolisation device comprising:
 a stem comprising a tube having a tube wall and a plurality of holes in the tube wall; and   a plurality of flexible bristles extending radially outwardly from the tube, wherein each hole has at least one of the plurality of flexible bristles penetrating through said hole;   wherein a filler material is disposed within a lumen of the tube to secure the at least one of the plurality of flexible bristles to the tube.   
     
     
         88 . The embolization device of  claim 87 , wherein the filler material is an adhesive. 
     
     
         89 . The embolization device of  claim 87 , wherein the filler material is a curable material or a settable material, and, optionally, wherein the filler material is curable or settable upon heating, solvent flashing and/or irradiating. 
     
     
         90 . The embolization device of  claim 87 , wherein the filler material adheres or bonds to the at least one of the plurality of flexible bristles, and/or wherein the filler material mechanically anchors the at least one of the plurality of flexible bristles. 
     
     
         91 . The embolization device of  claim 87 , wherein the filler material substantially fills the lumen of the tube. 
     
     
         92 . An embolization device for promoting clot formation in a bodily lumen and having a contracted delivery configuration and an expanded deployed configuration, the embolisation device comprising:
 a stem comprising a tube having a tube wall and a plurality of holes in the tube wall; and   a plurality of flexible bristles extending radially outwardly from the tube, wherein each hole has at least one of the plurality of flexible bristles penetrating through said hole;   further comprising a securing piece disposed within a lumen of the tube and configured to secure the at least one of the plurality of flexible bristles to the tube.   
     
     
         93 . The embolization device of  claim 92 , wherein a portion of the at least one of the plurality of flexible bristles is clamped between the securing piece and an inner surface of the tube wall. 
     
     
         94 . The embolization device of  claim 92 , wherein the securing piece is an inner mandrel, and wherein a portion of the at least one of the plurality of flexible bristles is clamped between an outer surface of the inner mandrel and an inner surface of the tube wall. 
     
     
         95 . The embolization device of  claim 92 , wherein a portion of the at least one of the plurality of flexible bristles which penetrates through the tube wall has a greater radius than a hole in the tube wall through which the bristle penetrates the tube wall. 
     
     
         96 . The embolization device of  claim 92 , wherein a portion of the at least one of the plurality of flexible bristles which penetrates through the tube wall comprises a rough portion. 
     
     
         97 . A method of manufacturing an embolization device for promoting clot formation in a lumen having a contracted delivery configuration and an expanded deployed configuration, the method comprising:
 providing a stem comprising a tube having a tube wall and a plurality of holes in the tube wall; and   providing a plurality of flexible bristles such that they extend radially outwardly from the tube,   wherein each hole has at least one of the plurality of flexible bristles penetrating through said hole;   the method comprising disposing a filler material within a lumen of the tube to secure the at least one of the plurality of flexible bristles to the tube.   
     
     
         98 . The method  claim 97 , wherein the filler material is an adhesive. 
     
     
         99 . The method of  claim 97 , wherein the filler material is cured or set, and, optionally, wherein the filler material is cured or set upon heating, solvent flashing and/or irradiating. 
     
     
         100 . The method of  claim 97 , wherein the filler material adheres or bonds to the at least one of the plurality of flexible bristles, and/or wherein the filler material mechanically anchors the at least one of the plurality of flexible bristles. 
     
     
         101 . The method of  claim 97 , wherein the filler material substantially fills the lumen of the tube. 
     
     
         102 . A method of manufacturing an embolization device for promoting clot formation in a lumen having a contracted delivery configuration and an expanded deployed configuration, the method comprising:
 providing a stem comprising a tube having a tube wall and a plurality of holes in the tube wall; and   providing a plurality of flexible bristles such that they extend radially outwardly from the tube,   wherein each hole has at least one of the plurality of flexible bristles penetrating through said hole;   the method comprising disposing a securing piece within a lumen of the tube so as to secure the at least one of the plurality of flexible bristles to the tube.   
     
     
         103 . The method of  claim 102 , wherein a portion of the at least one of the plurality of flexible bristles is clamped between the securing piece and an inner surface of the tube wall. 
     
     
         104 . The method of  claim 102 , wherein the securing piece is an inner mandrel, and wherein a portion of the at least one of the plurality of flexible bristles is clamped between an outer surface of the inner mandrel and an inner surface of the tube wall. 
     
     
         105 . The method of  claim 102 , wherein a portion of the at least one of the plurality of flexible bristles which penetrates through the tube wall has a greater radius than a hole in the tube wall through which the bristle penetrates the tube wall. 
     
     
         106 . The method of  claim 102 , comprising inserting a guide into a lumen of the tube such that a portion of the flexible bristle may be guided from the inside of the lumen through a hole to the outside of the tube.