Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith

Abstract

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R 1 and R 2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

1 . A composition for growing hair by topical application comprising:
 bimatoprost in free form or a pharmaceutically acceptable salt thereof, wherein the bimatoprost is contained in an amount of about 0.3% w/w to about 4% w/w;   at least one first compound selected from a fatty acid, fatty acid alcohol and fatty ester,   wherein said composition is formulated for topical administration to the skin.   
     
     
         2 . The composition of  claim 1 , wherein the first compound is a fatty acid. 
     
     
         3 . The composition of  claim 2 , wherein the fatty acid is saturated. 
     
     
         4 . The composition of  claim 2 , wherein the fatty acid is unsaturated. 
     
     
         5 . The composition of  claim 2 , wherein the fatty acid is selected from the group consisting of stearic acid, oleic acid, linoleic acid, and mixtures thereof. 
     
     
         6 . The composition of  claim 1 , wherein the first compound is a fatty ester. 
     
     
         7 . The composition of  claim 6 , wherein the fatty ester is saturated. 
     
     
         8 . The composition of  claim 6 , wherein the fatty ester is unsaturated. 
     
     
         9 . The composition of  claim 6 , wherein the fatty ester is selected from the group consisting of glyceryl monostearate, glyceryl monooleate, and ethyl ester of linoleic acid. 
     
     
         10 - 30 . (canceled)