Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases

Abstract

The present invention relates to pharmaceutical compositions, containing 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, (S) 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole or (S) [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, their use as pharmaceuticals for the treatment of retinal diseases, for retinal neuroprotection and vision enhancement.

What is claimed is: 
     
         1 . A method of treating retinitis pigmentosa in a subject in need of such treatment, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of (S) [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, or a tautomer thereof, or a pharmaceutically acceptable salt of any one of the foregoing. 
     
     
         2 . The method of  claim 1 , wherein the pharmaceutical composition is in the form of eye drops, a slow releasing pellet, a suspension, a gel, or an intraocular implant. 
     
     
         3 . The method of  claim 2 , wherein the pharmaceutical composition is in the form of eye drops. 
     
     
         4 . The method of  claim 2 , wherein the pharmaceutical composition is in the form of a slow releasing pellet. 
     
     
         5 . The method of  claim 2 , wherein the pharmaceutical composition is in the form of a suspension. 
     
     
         6 . The method of  claim 2 , wherein the pharmaceutical composition is in the form of a gel. 
     
     
         7 . The method of  claim 2 , wherein the pharmaceutical composition is in the form of an intraocular implant.