Bone putty for bone pore and void filling

Abstract

A bone pore or void filling composition is described. The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; a bone growth stimulator; and bioactive glass. A kit for containing the bone pore or void filling composition, and methods for using the composition to fill a bone pore or void are also described.

1 . A bone pore or void filling composition, comprising a mixture of:
 a collagen component comprising a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate;   a polyethylene glycol component comprising a blend of polyethylene glycol polymers having different molecular weights,   a calcium phosphate component comprising tricalcium phosphate; and   a glass component comprising bioactive glass,   wherein the tricalcium phosphate and the bioactive glass in the mixture are configured to fill bone pores of a size less than 600 microns.   
     
     
         2 . The composition of  claim 1 , wherein the tricalcium phosphate comprises particles having a size from 50 to 300 microns. 
     
     
         3 . The composition of  claim 1 , wherein the bioactive glass comprises particles having a size from 50 to 300 microns. 
     
     
         4 . The composition of  claim 1 , wherein the blend of polyethylene glycol polymers consists of a first and a second polyethylene glycol polymer having different molecular weights. 
     
     
         5 . The composition of  claim 4 , wherein the first polyethylene glycol polymer has molecular weight within the range of 1350 g/mol to 1650 g/mol and the second polyethylene glycol polymer has a molecular weight within the range of 350 g/mol to 650 g/mol. 
     
     
         6 . The composition of  claim 1 , wherein the bone pore filling composition comprises a type I collagen. 
     
     
         7 . The composition of  claim 1 , wherein the bone pore filling composition comprises a type I collagen-glycosaminoglycan coprecipitate 
     
     
         8 . The composition of  claim 1 , wherein the bioactive glass comprises from 3% to 7.5% by weight. 
     
     
         9 . The composition of  claim 1 , wherein the tricalcium phosphate comprises from 15% to 30% by weight. 
     
     
         10 . The composition of  claim 1 , wherein the weight percent of the type I collagen or the type I collagen-glycosaminoglycan coprecipitate is from 0.2% to 1.5%. 
     
     
         11 . The composition of  claim 1 , wherein the composition further comprises a hemostatic agent. 
     
     
         12 . A method of filling a bone pore or void, comprising administering a composition according to  claim 1  to the site of the bone pore or void. 
     
     
         13 . The method of  claim 12 , wherein the composition is manually applied to the bone pore or void. 
     
     
         14 . The method of  claim 12 , wherein the composition is applied to the bone pore or void using a syringe. 
     
     
         15 . The method of  claim 12 , wherein the bone pore has a diameter from 75 microns to 350 microns. 
     
     
         16 . The method of  claim 12 , wherein the composition is applied to a bone pore in spongy bone. 
     
     
         17 . The method of  claim 12 , wherein the composition is applied to a natural bone void. 
     
     
         18 . A bone pore or void filling kit, comprising:
 the bone pore or void filling composition of  claim 1 ;   a syringe for administering the composition; and   a sterile package for holding the composition and the syringe.   
     
     
         19 . The kit of  claim 18 , further comprising instructions for filling a bone pore. 
     
     
         20 . The kit of  claim 18 , wherein the blend of polyethylene glycol polymers consists of a first and a second polyethylene glycol polymer having different molecular weights.