Multifunctional smell test

Abstract

Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

What is claimed is: 
     
         1 . A multifunctional smell assessment kit, comprising:
 a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and   a system for registering if said odorous volatile compound is detected by a user, comprising:
 (a) a first query for obtaining a first input on whether the user detects, by olfaction, the odorous volatile compound, 
 (b) a second query for obtaining a second input on whether the user identifies the odor of the volatile compound, and 
 (c) a third query for obtaining a third input on an intensity of the odor as perceived by the user, 
 wherein (a), (b) and (c) may be in any order. 
   
     
     
         2 . The multifunctional smell assessment kit of  claim 1 , further comprising a second surface adhered by a second releasable adhesive not comprising the odorous volatile compound. 
     
     
         3 . The multifunctional smell assessment kit of  claim 2 , wherein the first surface or the second surface comprises plastic, rubber, silicone, or paper. 
     
     
         4 . The multifunctional smell assessment kit of  claim 2 , wherein the first or second releasable adhesive comprises a glue, a resin, a rubber adhesive, or an acrylic adhesive. 
     
     
         5 . The multifunctional smell assessment kit of  claim 2 , further comprising a panel adhered directly or indirectly to the first and second surfaces by the first and second releasable adhesives. 
     
     
         6 . The multifunctional smell assessment kit of  claim 5 , wherein the panel comprises paper, card stock, plastic, rubber, metal, or silicone. 
     
     
         7 . The multifunctional smell assessment kit of  claim 5 , wherein the first releasable adhesive temporarily adheres the first surface directly or indirectly to the panel while retaining the odorous volatile compound. 
     
     
         8 . The multifunctional smell assessment kit of  claim 5 , wherein the panel comprises a printed symbol or code indicative of the odor, or indicative of which whether the first or the second releasable adhesive not comprising the odorous volatile compound. 
     
     
         9 . The multifunctional smell assessment kit of  claim 5 , wherein the panel is indirectly adhered to the first and second surfaces, the first releasable adhesive is directly adhered to a third surface directly adhered to the panel, and the second releasable adhesive is directly adhered to a fourth surface directly adhered to the panel. 
     
     
         10 . The multifunctional smell assessment kit of  claim 1 , wherein the system comprises a first computer generated output comprising the first query, a second computer generated output comprising the second query, and a third computer generated output comprising the third query. 
     
     
         11 . A smell assessment method, comprising:
 administering a questionnaire to a subject suspected of having an olfactory impairment;   wherein the subject has received a panel comprising a first peelable surface adhered directly or indirectly to the panel by a first adhesive comprising an odorous volatile compound detectible by a person of ordinary olfactory ability, and undetectable by a person having an olfactory impairment, wherein the compound comprises an odor detectable by the person of ordinary olfactory ability and unidentifiable by the person having the olfactory impairment, and wherein the panel comprises a second peelable surface adhered directly or indirectly to the panel by a second adhesive not comprising the odorous volatile compound; and   wherein the questionnaire comprises:
 a first question or instruction for determining whether the subject detects, by olfaction, the odorous volatile compound in the first adhesive, 
 a second question or instruction for determining whether the subject identifies the odor of the volatile compound, and 
 a third question or instruction for determining an intensity of the odor as perceived by the subject. 
   
     
     
         12 . The smell assessment method of  claim 11 , wherein the first question or instruction comprises a question or instruction to determine which of the first peelable surface and the second peelable surface the subject considers to comprise a stronger odor. 
     
     
         13 . The smell assessment method of  claim 11 , wherein the second question or instruction comprises a question or instruction to determine which of a first image or a second image comprises an image corresponding to the odor, wherein the first image comprises an image corresponding to the odor, and wherein the second image comprises an image not corresponding to the odor. 
     
     
         14 . The smell assessment method of  claim 11 , wherein the third question or instruction comprises a question or instruction to determine a quantitation of the intensity of the odor as perceived by the subject. 
     
     
         15 . The smell assessment method of  claim 11 , further comprising: identifying the subject as having the olfactory impairment or as having the olfactory impairment based on the subject's response to the first, second, or third question or instruction. 
     
     
         16 . The smell assessment method of  claim 15 , further comprising: identifying the subject as likely to have a disease or disorder when the subject is identified as having the olfactory impairment, and identifying the subject as unlikely to have the disease or disorder when the subject is identified as not having the olfactory impairment. 
     
     
         17 . The smell assessment method of  claim 16 , wherein the disease or disorder comprises coronavirus disease 2019 (COVID-19). 
     
     
         18 . The smell assessment method of  claim 17 , further comprising administering to the subject a COVID-19 treatment. 
     
     
         19 . The smell assessment method of  claim 16 , wherein the disease or disorder comprises a traumatic brain injury, Parkinson's disease or Alzheimer's disease. 
     
     
         20 . The smell assessment method of  claim 19 , further comprising administering to the subject a traumatic brain injury treatment, Parkinson's disease treatment or an Alzheimer's disease treatment.