Moisturizing compositions and uses thereof

Abstract

Embodiments herein are directed to moisturizing compositions comprising interpenetrating polymer networks, methods of making moisturizing compositions and methods of using moisturizing compositions.

1 - 26 . (canceled) 
     
     
         27 . A method of exfoliating skin comprising administering a topical composition comprising:
 about 61.5% to about 90% of urea and one or more components selected from the group consisting of an active agent, a keratinocyte differentiation promoting agent, a preservative system, an additional humectant, and combinations thereof, and   about 10% to about 38.5% of an interpenetrating polymer network (IPN) composition, wherein the IPN composition comprises:
 about 0.01% w/w to about 5% w/w of crosslinked gellan gum of the IPN composition, 
 about 0.01% w/w to about 5% w/w of cetyl hydroxyethylcellulose of the IPN composition, 
 about 0.01% w/w to about 5% w/w of sodium hyaluronate of the IPN composition, 
 about 0.01% w/w to about 5% w/w of a mono-, or di-valent ion, and 
 about 25% w/w to about 80% w/w of a humectant, of the IPN composition, 
   wherein the cetyl hydroxyethylcellulose and the sodium hyaluronate are interlaced; and   wherein the crosslinked gellan gum is crosslinked via ionic bonds, through the mono-, or di-valent ion, and entraps the interlaced cetyl hydroxyethylcellulose, the sodium hyaluronate, and the humectant to form the interpenetrating polymer network moisturizing topical composition.   
     
     
         28 . The method of  claim 27 , wherein the exfoliation occurs by promoting the digestion of desmosomes, normalizing cell maturation, modulating keratinocyte function, normalizing keratinocyte differentiation, normalizing keratinocyte proliferation, modulating phosphatidylglycerol content of keratinocytes, or any combination thereof. 
     
     
         29 . The method of  claim 27 , wherein the humectant are in an amount of about 30% w/w of the IPN composition. 
     
     
         30 . The method of  claim 29 , wherein the at least one additional humectant is glycerin. 
     
     
         31 . The method of  claim 27 , wherein the mono-, or di-valent ion is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid and related salts including Calcium PCA, Sodium PCA, Zinc PCA, Magnesium PCA, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof. 
     
     
         32 . The method of  claim 27 , wherein the mono-, or di-valent ion is selected from calcium PCA, magnesium PCA, and combinations thereof. 
     
     
         33 . The method of  claim 27 , wherein the humectant is selected from the group consisting of glycerin, diglycerin, betaine, diols, propylene glycol, butylene glycol, pentylene glycol, propanediol, 1,2-hexanediol, D-ribose, glucose, sorbitol, dextrose, urea, 2-Pyrrolidone-5-Carboxylic Acid and related salts, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, ectoin, lactic acid, betaine, glycolic acid, lactobionic acid, and any combination thereof. 
     
     
         34 . The method of  claim 27 , wherein the topical composition is formulated as a liquid, emulsion, suspension, triturate, adhesive, jelly, foam, paste, ointment, shampoo, cream, serum, milk, lotion, salve, oil, butter, gel, or balm. 
     
     
         35 . The method of  claim 27 , wherein the active agent is selected from the group consisting of a skin treatment, a skin protectant, an acne treatment, a wrinkle treatment, an exfoliating acid, a skin brightening agent, and combinations thereof. 
     
     
         36 . The method of  claim 35 , wherein the acne treatment is selected from the group consisting of benzoyl peroxide, salicylic acid, willowbark extract, poly hydroxyacid, tannic acid, hydroxybenzoic acid, juniperic acid, tartaric acid, glycolic acid, lactic acid, citric acid, and combinations thereof. 
     
     
         37 . The method of  claim 35 , wherein the wrinkle treatment is selected from the group consisting of retinol, antioxidants, vitamin A, retinoid, tretinoin, tazarotene, and combinations thereof. 
     
     
         38 . The method of  claim 35 , wherein the exfoliating acid is selected from the group consisting of glycolic acid, alpha hydroxyl acid (AHA), polyhydroxyacid, and combinations thereof. 
     
     
         39 . The method of  claim 35 , wherein the skin brightening agent is selected from the group consisting of hydroquinone, hexyl resorcinol, phenylethyl resorcinol, and combinations thereof. 
     
     
         40 . The method of  claim 27 , wherein the preservative system is selected from the group consisting of phenoxyethanol, capryl glycol, ethylhexylglycerin, hexylene glycol, sodium benzoate, potassium sorbate, methyl paraben, gluconolactone, lactic acid, sorbic acid, glyceryl caprylate, glyceryl undecylenate, ethanol, chlorphenesin, salicylic acid or any combination thereof. 
     
     
         41 . The method of  claim 27 , wherein the keratinocyte differentiation promoting agent is selected from the group consisting of phosphatidylglycerol, an organic salt of glycerophosphoinositol, calcium PCA, calcium lactate, calcium citrate or other forms of soluble calcium, hydroxyapatite, cortisone, ceramides, ergocalciferol, cholecalciferol, sphingolipids, and any combination thereof.