Filamentary devices for treatment of vascular defects

Abstract

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

What is claimed is: 
     
         1 . A device for treatment of a patient's cerebral aneurysm, comprising:
 a first permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh, the expanded state having a proximal portion, a distal portion, and an interior cavity, wherein each of the plurality of filaments has a proximal end and a distal end, and wherein the proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub; and   a second permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state of the second permeable shell, and a plurality of elongate filaments that are woven together to form a mesh, wherein at least a portion of the second permeable shell is in contact with the proximal portion of the first permeable shell, wherein each of the plurality of filaments of the second permeable shell has a proximal end and a distal end,   wherein the proximal ends of each of the plurality of filaments of the second permeable shell are gathered in the proximal hub with the proximal ends of each of the plurality of filaments of the first permeable shell,   wherein the distal ends of each of the plurality of filaments of the second permeable shell are not bound together, and   wherein a length of the expanded state of the second permeable shell is smaller than a length of the expanded state of the first permeable shell.   
     
     
         2 . The device of  claim 1 , wherein the second permeable shell is stiffer than the first permeable shell. 
     
     
         3 . The device of  claim 1 , wherein an outer surface of the second permeable shell is in contact with an inner surface of the first permeable shell. 
     
     
         4 . The device of  claim 1 , wherein the length of the expanded state of the second permeable shell is between about 10% to about 40% of the length of the expanded state of the first permeable shell. 
     
     
         5 . The device of  claim 1 , wherein the second permeable shell is attached to the first permeable shell by welding, adhesive, or mechanical ties. 
     
     
         6 . The device of  claim 1 , wherein a diameter of each of the plurality of filaments of the second permeable shell is larger than a diameter of each of the plurality of filaments of the first permeable shell. 
     
     
         7 . A device for treatment of a patient's cerebral aneurysm, comprising:
 a first self-expanding mesh including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form the first self-expanding mesh, the expanded state having a proximal portion, a distal portion, and an interior cavity, wherein each of the plurality of filaments has a proximal end and a distal end, and wherein the proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub; and   a second self-expanding mesh including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state of the second self-expanding mesh, and a plurality of elongate filaments that are woven together to form the second self-expanding mesh, wherein at least a portion of the second self-expanding mesh is in contact with the proximal portion of the first self-expanding mesh, wherein each of the plurality of filaments of the second self-expanding mesh has a proximal end and a distal end,   wherein the proximal ends of each of the plurality of filaments of the second self-expanding mesh are gathered in the proximal hub with the proximal ends of each of the plurality of filaments of the first self-expanding mesh,   wherein the distal ends of each of the plurality of filaments of the second self-expanding mesh are not bound together, and   wherein a length of the expanded state of the second self-expanding mesh is smaller than a length of the expanded state of the first self-expanding mesh.   
     
     
         8 . The device of  claim 7 , wherein the second self-expanding mesh is stiffer than the first self-expanding mesh. 
     
     
         9 . The device of  claim 7 , wherein an outer surface of the second self-expanding mesh is in contact with an inner surface of the first self-expanding mesh. 
     
     
         10 . The device of  claim 7 , wherein the length of the expanded state of the second self-expanding mesh is between about 10% to about 40% of the length of the expanded state of the first self-expanding mesh. 
     
     
         11 . The device of  claim 7 , wherein the second self-expanding mesh is attached to the first self-expanding mesh by welding, adhesive, or mechanical ties. 
     
     
         12 . The device of  claim 7 , wherein a diameter of each of the plurality of filaments of the second self-expanding mesh is larger than a diameter of each of the plurality of filaments of the first self-expanding mesh. 
     
     
         13 . A device for treatment of a patient's cerebral aneurysm, comprising:
 a first permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh, the expanded state having a proximal portion, a distal portion, and an interior cavity, wherein each of the plurality of filaments has a proximal end and a distal end, and wherein the proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub; and   a second permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh, wherein at least a portion of the second permeable shell is in contact with the proximal portion of the first permeable shell, wherein each of the plurality of filaments has a proximal end and a distal end,   wherein the second permeable shell has an open distal end, wherein the distal ends of each of the plurality of filaments of the second permeable shell are not bound together, and wherein a length of the expanded state of the second permeable shell is smaller than a length of the expanded state of the first permeable shell.   
     
     
         14 . The device of  claim 13 , wherein the second permeable shell is stiffer than the first permeable shell. 
     
     
         15 . The device of  claim 13 , wherein the second permeable shell is attached to the first permeable shell by welding, adhesive, or mechanical ties. 
     
     
         16 . The device of  claim 13 , wherein the distal ends of each of the plurality of filaments of the second permeable shell are not attached to the first permeable shell. 
     
     
         17 . The device of  claim 13 , wherein the proximal ends of each of the plurality of filaments of the second permeable shell are gathered in the proximal hub with the proximal ends of each of the plurality of filaments of the first permeable shell. 
     
     
         18 . The device of  claim 13 , wherein a diameter of each of the plurality of filaments of the second permeable shell is larger than a diameter of each of the plurality of filaments of the first permeable shell.