Protein based cannabis compositions

Abstract

Described herein are novel compositions comprising a cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpenoid; and a protein, selected from the group consisting of whey and a plant protein. According to an embodiment, the cannabis component is non-covalently bound to the whey or to the plant protein. The plant protein may be selected from the group consisting of: soy protein, pea protein, rice protein, hemp protein, and hops protein or other plant derived protein.

1 . A composition comprising a cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpene; and a protein, selected from the group consisting of whey and a plant protein, wherein the cannabis component is non-covalently bound to the protein, and wherein the ratio of cannabis component to protein, by weight, is between 0.008 to 1 and 1.2 to 1. 
     
     
         2 . The composition according to  claim 1  wherein the cannabis component is a cannabinoid. 
     
     
         3 . The composition according to  claim 2  wherein the cannabinoid is THC or CBD. 
     
     
         4 . The composition according to  claim 1  wherein the protein is whey proteins. 
     
     
         5 . The composition according to  claim 1  wherein the protein is a plant protein. 
     
     
         6 . The composition according to  claim 5  wherein the plant protein is selected from the group consisting of: soy proteins, pea proteins, rice proteins, hemp proteins, and hops proteins. 
     
     
         7 . (canceled) 
     
     
         8 . The composition according to  claim 1  wherein the ratio of cannabis component to protein, by weight, is between 0.025 to 1 and 0.5 to 1. 
     
     
         9 . A composition comprising a cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpene; and a protein, selected from the group consisting of whey and a plant protein, wherein the cannabis component is non-covalently bound to the protein, and wherein the protein comprises a water-suspended fraction of the protein. 
     
     
         10 . The composition according to  claim 1 , wherein the protein has an average molecular weight of between 1 and 100 kilodalton (kDa). 
     
     
         11 . The composition according to  claim 10  wherein the protein has an average molecular weight of between 30-67 kDa. 
     
     
         12 . The composition according to  claim 1 , wherein when the composition is in aqueous form at a cannabinoid concentration of 2 mg/ml and undergoes centrifugation at 3,300 RPM for 1 minute, the cannabis component remains suspended. 
     
     
         13 . (canceled) 
     
     
         14 . The composition according to  claim 1  in the form of a candy, a chocolate, cookies, a sauce, a composition for sprinkling on food, a popsicle, a protein shake powder a beverage, a beer, a soft drink, alcoholic beverage, juice, gummy and a milkshake. 
     
     
         15 . The composition according to  claim 1  in a dry solid form. 
     
     
         16 . The composition according to  claim 1  and further comprising gelatin or pectin or agar-agar. 
     
     
         17 . A method for treatment of a disease comprising administering to a patient in need thereof a composition according to  claim 1  in a pharmaceutical dosage form. 
     
     
         18 - 20 . (canceled) 
     
     
         21 . A method for manufacture of a composition comprising a cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpene; and a protein, selected from the group consisting of whey and a plant protein, wherein the cannabis component is non-covalently bound to the protein, comprising:
 dissolving a cannabis component in an organic solvent to form an organic solution; and   combining the organic with an aqueous protein solution to form a crude cannabis-protein complex.   
     
     
         22 . The method according to  claim 21  further comprising forming a complex between the cannabis component and the protein using nanoprecipitation or emulsification. 
     
     
         23 . The method according to  claim 22  further comprising removing the residual organic solvent. 
     
     
         24 . The method according to  claim 23  further comprising removing the residual water solvent. 
     
     
         25 - 27 . (canceled)