US2022265747A1PendingUtilityA1

Compositions, Methods, and Medical Compositions for Treatment of and Maintaining the Health of the Liver

Assignee: UNIGEN INCPriority: Jul 15, 2015Filed: May 9, 2022Published: Aug 25, 2022
Est. expiryJul 15, 2035(~9 yrs left)· nominal 20-yr term from priority
A61K 36/79A61K 31/7048A61K 36/886A61P 43/00A61K 2236/53A61K 36/282A61K 45/06A61P 1/16A61K 2236/333A61K 2236/33A61K 2236/51
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Claims

Abstract

Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract, at least one Aloe gel powder, and at least one Schizandra extract. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract enriched for at least one polymer or biopolymer, at least one Aloe gel powder enriched for at least one chromone, and at least one Schizandra extract enriched for at least one lignan and organic acid.

Claims

exact text as granted — not AI-modified
1 .- 38 : (canceled) 
     
     
         39 . A composition for treatment of and maintaining the health of the liver, comprising a mixture of plant extracts, wherein the plant extracts comprise at least one  Artemisia  extract, at least one  Aloe  gel powder, and at least one  Schizandra  extract. 
     
     
         40 . A composition for treatment of and maintaining the health of the liver, comprising a mixture of plant extracts from an  Artemisia  extract enriched for at least one polymer or biopolymer, an  Aloe  gel powder enriched for at least one chromone, and a  Schizandra  extract enriched for at least one lignan and organic acid. 
     
     
         41 . The composition of  claim 39 , wherein the  Artemisia  extract and the  Schizandra  extract are blended in a weight ratio from 4:1 to 1:4. 
     
     
         42 . The composition of  claim 39 , wherein the  Aloe  gel powder are further blended with a mixture of  Artemisia  and  Schizandra  extracts in a weight percentage of about 5% to about 50%. 
     
     
         43 . The composition of  claim 39 , wherein the mixture of  Artemisia, Schizandra  and  Aloe  leaf gel powder is in a ratio of 8:4:3. 
     
     
         44 . The composition of  claim 40 , wherein the  Artemisia  extract comprises 0.01% to 99.9% of biopolymers with molecular weight higher than 500. 
     
     
         45 . The composition of  claim 39 , wherein the  Artemisia  extract comprises  Artemisia absinthium, Artemisia abrotanum  L.,  Artemisia afra, Artemisia annua  L,  Artemisia arborescens, Artemisia asiatica, Artemisia campestris, Artemisia deserti, Artemisia iwayomogi, Artemisia ludoviciana, Artemisia vulgaris, Artemisia oelandica, Artemisia princeps  Pamp,  Artemisia sacrorum, Artemisia scoparia, Artemisia stelleriana, Artemisia frigida  Willd,  Artemisia  anethoides Mattf.,  Artemisia anethifolia  Weber.,  Artemisia  faurier Nakai,  Origanum vulgare, Siphenostegia chinensis , or any combination thereof. 
     
     
         46 . The composition of  claim 40 , wherein the  Artemisia  extract is selected from  Artemisia absinthium, Artemisia abrotanum  L.,  Artemisia afra, Artemisia annua  L,  Artemisia arborescens, Artemisia asiatica, Artemisia campestris, Artemisia deserti, Artemisia iwayomogi, Artemisia ludoviciana, Artemisia vulgaris, Artemisia oelandica, Artemisia princeps  Pamp,  Artemisia sacrorum, Artemisia scoparia, Artemisia stelleriana, Artemisia frigida  Willd,  Artemisia  anethoides Mattf.,  Artemisia anethifolia  Weber.,  Artemisia  faurier Nakai,  Origanum vulgare, Siphenostegia chinensis , or any combination thereof. 
     
     
         47 . The composition of  claim 40 , wherein the one or more biopolymers are extracted from  Artemisia  plant with water, methanol, ethanol, alcohol, a water-mixed solvent or a combination thereof. 
     
     
         48 . The composition of  claim 39 , wherein the  Aloe  gel powder comprises  Aloe arborescens, Aloe barbadensis, Aloe cremnophila, Aloe ferox, Aloe saponaria, Aloe vera, Aloe vera  var.  chinensis  or a combination thereof. 
     
     
         49 . The composition of  claim 40 , wherein the at least one chromone composition comprises about 0.01% to about 100% of one or more chromones 
     
     
         50 . The composition of  claim 40 , wherein the at least one chromone is selected from aloesin, aloesinol, aloeresin A, aloeresin B, aloeresin C, aloeresin D, aloeresin E or any combination thereof. 
     
     
         51 . A composition of  claim 40 , wherein the chromone composition comprises about 1% to about 4% of Aloesin, wherein the composition is essentially free of anthroquinones and wherein the  Aloe  gel is isolated from a plant selected from  Aloe  barbadensis or  Aloe vera ; and wherein the at least one chromone is isolated from  Aloe vera  or  Aloe ferox  or any combination thereof. 
     
     
         52 . The composition of  claim 39 , wherein the  Schizandra  comprises  Schisandra chinensis, Schisandra elongate, Schisandra glabra, Schisandra glaucescens, Schisandra henryi, Schisandra incarnate, Schisandra lancifolia, Schisandra neglecta, Schisandra nigra, Schisandra propinqua, Schisandra pubescens, Schisandra repanda, Schisandra rubriflora, Schisandra rubrifolia, Schisandra sinensis, Schisandra sphaerandra, Schisandra sphenanthera, Schisandra tomentella, Schisandra tuberculate, Schisandra vestita, Schisandra viridis, Schisandra wilsoniana  or a combination thereof. 
     
     
         53 . The composition of  claim 40 , wherein the at least one lignan is isolated from a  Schizandra  extract is Schisandrin, Deoxyschizandrin, γ-Schizandrin, Pseudo-γ-schizandrin, Wuweizisu B, Wuweizisu C, Isoschizandrin, Pregomisin, eoschizandrin, Schizandrol, Schizandrol A, Schizandrol B, Schisantherin A, B, C, D, E, Rubschisantherin, Schisanhenol acetdte, Schisanhenol B, Schisanhenol, Gomisin A, B, C, D, E, F, G, H, J, N, O, R, S, T, U, Epigomisin O, Angeloylgomisin H, O, Q, T, igloylgomisin H, P, Angeloyisogomisin O, Benzoyl-gomisin H, O, P, Q, Benzoyl-isogomisin or a combination thereof. 
     
     
         54 . The composition of  claim 40 , wherein the at least one organic acid is isolated from a  Schizandra  extract includes malic acid, citric acid, shikimic acid or a combination thereof. 
     
     
         55 . The composition of  claim 39 , wherein the plant extracts are derived from at least one plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves, other aerial parts or a combination thereof. 
     
     
         56 . The composition of  claim 40 , wherein the plant extracts are derived from at least one plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves, other aerial parts or a combination thereof. 
     
     
         57 . The composition of  claim 40 , wherein the composition additionally comprises at least one liver protectant. 
     
     
         58 . The composition of  claim 57 , wherein the liver protectant comprises plant powder or plant extract of milk thistle,  curcuma , bupleurum, licorice,  salvia, morus , hovenia, agrimony, cudrania, lyceum, citrus,  prunus , yellow mume, Korea gim, dandelion,  vitis , grape seed,  rubus, camellia , green tea, krill oil, yeast, soy bean; isolated and enriched silymarins, flavonoids, phospholipids, thios, pycnogenols, gelatins, soy lecithin, pancreatic enzymes; natural or synthetic N-acetyl-cysteine, taurine, riboflavin, niacin, pyridoxine, folic acid, carotenes, vitamin A, vitamin B2, B6, B16, vitamin C, vitamin E, glutathione, branched-chain amino acids, selenium, copper, zinc, manganese, coenzyme Q10, L-arginine, L-glutamine, phosphatidylcholine or a combination thereof. 
     
     
         59 . The composition of  claim 40 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient.

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