US2022267317A1PendingUtilityA1

Benzoquinoline Inhibitors of Vesicular Monoamine Transporter 2

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Assignee: AUSPEX PHARMACEUTICALS INCPriority: Sep 18, 2008Filed: Nov 5, 2021Published: Aug 25, 2022
Est. expirySep 18, 2028(~2.2 yrs left)· nominal 20-yr term from priority
Inventors:Thomas G. GantManouchehr Shahbaz
A61K 31/4745C07B 2200/05C07B 59/00A61P 1/16A61P 25/18A61P 25/14C07D 455/06A61P 25/00A61K 45/06A61P 21/00A61P 43/00A61P 25/16C07B 59/002
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Claims

Abstract

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.

Claims

exact text as granted — not AI-modified
1 . A compound of structural Formula I 
       
         
           
           
               
               
           
         
         or a salt thereof, wherein:
 R 1 -R 27  are independently selected from the group consisting of hydrogen and deuterium; and at least one of R 1 -R 27  is deuterium.

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