Compositions and methods for treating eczema

Abstract

Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of eczema. The compositions may include propionic acid and/or non-steroidal esters of propionic acid. The compositions may further include a corticosteroid, immunomodulator, antibiotic, antibody, colloidal oatmeal, conditioned media prepared by bacterial fermentation, short chain fatty acids, picolinic acid, or emollient. The method of treatment may include analysis of the skin microbiome.

What is claimed is: 
     
         1 . A method of treating atopic dermatitis (AD), the method comprising administering to a subject in need thereof, a composition consisting of
 a non-steroidal ester of propionic acid, and   at least one ingredient selected from the group consisting of an antimicrobial agent, an anti-inflammatory agent, an immunomodulator, an antibiotic, colloidal oatmeal, succinic acid, butyric acid, conditioned media prepared by microbial fermentation, and an emollient, in a pharmaceutically acceptable topical preparation.   
     
     
         2 . The method of  claim 1 , wherein the non-steroidal ester of propionic acid is selected from the group consisting of tripropionin (Tri-PA), 2-(2-propionyloxyethoxy)ethylester (PA-DEG-PA), ester of glycerol and propionic acid (PA-glycerol-PA), (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate (M-PA), 2-[2-(propionyloxy)ethoxy]ethyl propionate (di-PA), propionylcholineiodide (ch-PA), and propionyl-L-carnitine (ca-PA). 
     
     
         3 . The method of  claim 1 , wherein the non-steroidal ester of propionic acid is tripropionin (Tri-PA). 
     
     
         4 . The method of  claim 1 , wherein the non-steroidal ester of propionic acid is present in the composition in an amount from about 0.5 w/w % to about 10 w/w %. 
     
     
         5 . The method of  claim 1 , wherein the non-steroidal ester of propionic acid is Triporopionin (Tri-PA) present in the composition in an amount from about 0.5 w/w % to about 10 w/w %. 
     
     
         6 . The method of  claim 1 , wherein the at least one ingredient is colloidal oatmeal. 
     
     
         7 . The method of  claim 1 , wherein the at least one ingredient is an anti-inflammatory agent. 
     
     
         8 . The method of  claim 7 , wherein the anti-inflammatory agent is a corticosteroid. 
     
     
         9 . The method of  claim 1 , wherein the at least one ingredient is an antibiotic. 
     
     
         10 . The method of  claim 1 , wherein the at least one ingredient is an emollient. 
     
     
         11 . The method of  claim 1 , wherein the at least one ingredient is an immunomodulator. 
     
     
         12 . The method of  claim 1 , wherein the at least one ingredient is succinic acid or butyric acid. 
     
     
         13 . The method of  claim 1 , wherein the at least one ingredient is conditioned media prepared by microbial fermentation. 
     
     
         14 . The method of  claim 1 , wherein the at least one ingredient is an antimicrobial agent. 
     
     
         15 . The method of  claim 3 , wherein the Tri-PA is present in the composition in an amount from about 0.5 w/w % to about 10 w/w %.