Coated silk films, methods for the production thereof and uses thereof

Abstract

The present invention relates to coated silk films. Further, the present invention relates to pharmaceutical or cosmetic compositions comprising the coaled silk films. Furthermore, the present invention relates to coated silk films or pharmaceutical compositions comprising the coated silk films for use in medicine. In addition, the present invention relates to methods of producing the coated silk films.

1 - 78 . (canceled) 
     
     
         79 . A coated silk film comprising
 (i) an active agent release sheet which comprises one or more first silk film layers comprising at least one active agent,
 wherein the active agent release sheet comprises (1) a top surface and a base surface, which are opposed to each other, and (2) at least one side surface connecting the top and the base surfaces, and 
   (ii) one or more release modifying layers completely covering the active agent release sheet,   
     
     
         80 . The coated silk film of  claim 79 , wherein the coated silk film is a self-supporting silk film without carrier element. 
     
     
         81 . The coated silk film of  claim 79 , wherein the active agent release sheet comprises one or more second silk film layers. 
     
     
         82 . The coated silk film of  claim 79 , wherein the active agent is selected from the group consisting of a biological agent, a pharmaceutical agent, a cosmetic agent, a nutrient, and a dietary supplement. 
     
     
         83 . The coated silk film of  claim 79 , wherein the one or more first silk film layers comprise at least one silk polypeptide. 
     
     
         84 . The coated silk film of  claim 83 , wherein the at least one silk polypeptide is a spider silk polypeptide. 
     
     
         85 . The coated silk film of  claim 81 , wherein the one or more second silk film layers comprise at least one silk polypeptide. 
     
     
         86 . The coated silk film of  claim 85 , wherein the at least one silk polypeptide is a spider silk polypeptide. 
     
     
         87 . The coated silk film of  claim 79 , wherein the one or more first silk film layers have a homogenous structure (i.e. are not porous). 
     
     
         88 . The coated silk film of  claim 81 , wherein the one or more second silk film layers have a homogenous structure (i.e. are not porous). 
     
     
         89 . The coated silk film of  claim 79 , wherein the one or more release modifying layers have a homogenous structure (i.e. are not porous). 
     
     
         90 . A pharmaceutical composition comprising the coated silk film of  claim 79 , wherein the active agent is a pharmaceutical agent. 
     
     
         91 . A cosmetic composition comprising the coated silk film of  claim 79 , wherein the active agent is a cosmetic agent. 
     
     
         92 . A method of producing a coated silk film comprising the steps of:
 (i) providing an active agent release sheet which comprises one or more first silk film layers comprising at least one active agent,
 wherein the active agent release sheet comprises (1) a top surface and a base surface, which are opposed to each other, and (2) at least one side surface connecting the top and the base surfaces, and 
   (ii) completely covering the active agent release sheet with one or more release modifying layers.   
     
     
         93 . The method of  claim 92 , wherein the coated silk film is a self-supporting silk film without carrier element. 
     
     
         94 . The method of  claim 92 , wherein the active agent release sheet comprises one or more second silk film layers. 
     
     
         95 . The method of  claim 92 , wherein the active agent is selected from the group consisting of a biological agent, a pharmaceutical agent, a cosmetic agent, a nutrient, and a dietary supplement. 
     
     
         96 . The method of  claim 92 , wherein the one or more first silk film layers comprise at least one silk polypeptide. 
     
     
         97 . The method of  claim 96 , wherein the at least one silk polypeptide is a spider silk polypeptide. 
     
     
         98 . The method of  claim 94 , wherein the one or more second silk film layers comprise at least one silk polypeptide. 
     
     
         99 . The method of  claim 98 , wherein the at least one silk polypeptide is a spider silk polypeptide. 
     
     
         100 . The method of  claim 92 , wherein the one or more first silk film layers have a homogenous structure (i.e. are not porous). 
     
     
         101 . The method of  claim 94 , wherein the one or more second silk film layers have a homogenous structure (i.e. are not porous). 
     
     
         102 . The method of  claim 92 , wherein the one or more release modifying layers have a homogenous structure (i.e. are not porous).