Sorbent particles for sample treatment

Abstract

Novel sorbents, devices, kits and methods useful for sample treatment are disclosed herein.

1 - 34 . (canceled) 
     
     
         35 . Inorganic/organic hybrid sorbent particles comprising an organic copolymer that comprises at least one hydrophilic organic monomer, at least one hydrophobic organic monomer, and at least one alkenyl-functionalized organosilane monomer, wherein the particles are modified by the addition of a C4-C60 alkyl component. 
     
     
         36 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the particles are modified by hydrolytic condensation of a C4-C60-alkyl-functionalized organosilane compound. 
     
     
         37 . The inorganic/organic hybrid sorbent particles of  claim 36 , wherein the C4-C60-alkyl-functionalized organosilane compound is a compound of the formula RSiZ 1 Z 2 Z 3 , where R is C4-C60 alkyl and where Z 1 , Z 2  and Z 3  are independently selected from Cl, Br, I, C1-C4 alkoxy, C1-C4 alkylamino, and C1-C4 alkyl, although at most two of Z 1 , Z 2  and Z 3  can be C1-C4 alkyl. 
     
     
         38 . inorganic/organic hybrid sorbent particles of  claim 36 , wherein the C4-C60-alkylorganosilane is selected from octadecyltrimethoxysilane, octadecyltriethoxysilane, octadecyltrichlorosilane, octadecyltri(dimethylamino)silane, methyloctadecyldimethoxysilane, methyloctadecyldiethoxysilane, methyloctadecyldichlorosilane, methyloctadecyldi(dimethylamino)silane, dimethyloctadecylmethoxysilane, dimethyloctadecylethoxysilane, dimethyloctadecylchlorosilane, dimethyloctadecyldimethylaminosilane, diisopropyloctadecylmethoxysilane, diisopropyloctadecylethoxysilane, diisopropyloctadecylchlorosilane, diisopropyloctadecyldimethylaminosilane, octyltrimethoxysilane, octyltriethoxysilane, octyltrichlorosilane, octyltri(dimethylamino)silane, methyloctyldimethoxysilane, methyloctyldiethoxysilane, methyloctyldichlorosilane, methyloctyldi(dimethylamino)silane, dimethyloctylmethoxysilane, dimethyloctylethoxysilane, dimethyloctylchlorosilane, dimethyloctyldimethylaminosilane, diisopropyloctylmethoxysilane, diisopropyloctylethoxysilane, diisopropyloctylchlorosilane, diisopropyloctyldimethylaminosilane, butyltrimethoxysilane, butyltriethoxysilane, butyltrichlorosilane, butyltri(dimethylamino)silane, methylbutyldimethoxysilane, methylbutyldiethoxysilane, methylbutyldichlorosilane, methylbutyldi(dimethylamino)silane, dimethylbutylmethoxysilane, dimethylbutylethoxysilane, dimethylbutylchlorosilane, dimethylbutyldimethylaminosilane, diisopropylbutylmethoxysilane, diisopropylbutylethoxysilane, diisopropylbutylchlorosilane, and diisopropylbutyldimethylaminosilane. 
     
     
         39 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the alkenyl-functionalized organosilane monomer is selected from 3-(trimethoxysilyl)propyl methacrylate (MAPTMOS) and vinyltriethoxysilane (VTES). 
     
     
         40 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the hydrophilic organic monomer comprises a monomer having the following formula, 
       
         
           
           
               
               
           
         
       
       where n ranges from 1-3. 
     
     
         41 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the hydrophobic organic monomer comprises divinylbenzene and, optionally, styrene. 
     
     
         42 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises an organic monomer that comprises one or more sulfonate groups. 
     
     
         43 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises a divinylbenzene monomer that comprises one or more sulfonate groups. 
     
     
         44 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises an organic monomer that comprises one or more quaternary ammonium groups. 
     
     
         45 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises an organic monomer that comprises one or more —R 1 N + R 2 R 3 R 4  groups, where R 1  is a C1-C8 alkylene group, and R 2 , R 3  and R 4  are C1-C8 alkyl groups and may be the same or different. 
     
     
         46 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises a divinylbenzene monomer that comprises one or more-R 1 N + R 2 R 3 R 4  groups, where R 1  is a C1-C8 alkylene group, and R 2 , R 3  and R 4  are C1-C8 alkyl groups and may be the same or different. 
     
     
         47 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises an organic monomer that comprises one or more carboxyl groups. 
     
     
         48 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises a divinylbenzene monomer that comprises one or more carboxyl groups. 
     
     
         49 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises an organic monomer that comprises one or more primary, secondary or tertiary amine groups. 
     
     
         50 . The inorganic/organic hybrid sorbent particles of  claim 35 , wherein the organic copolymer further comprises a divinylbenzene monomer that comprises one or more piperazine groups.