Oral Care Composition Comprising Rottlerin

Abstract

An oral care composition including rottlerin in an amount sufficient to reduce a growth of gram-positive bacteria in a mouth treated with the oral care composition.

1 . An oral care composition, comprising rottlerin in an amount sufficient to reduce a growth of gram-positive bacteria in a mouth treated with the oral care composition, wherein the oral care composition is a dentifrice comprising from 0.01 weight % to 1.0 weight % of an antibacterial agent, based on the total weight of the oral care composition, wherein the antibacterial agent comprises rottlerin. 
     
     
         2 . (canceled) 
     
     
         3 . The oral care composition of  claim 1 , comprising from 0.05 weight % to 1.0 weight % rottlerin. 
     
     
         4 . The oral care composition of  claim 1 , wherein the antibacterial agent consists essentially of rottlerin. 
     
     
         5 . The oral care composition of  claim 1 , wherein the antibacterial agent comprises from 0.10 weight % to 0.75 weight % rottlerin, based on the total weight of the oral care composition. 
     
     
         6 . The oral care composition of  claim 1 , wherein the oral care composition lacks another gram-positive antibacterial ingredient other than rottlerin. 
     
     
         7 . The oral care composition of  claim 1 , wherein rottlerin is the only gram-positive antibacterial ingredient. 
     
     
         8 . A method for increasing the antibacterial effect of an oral care composition, comprising:
 adding an antibacterial agent to the oral care composition,   wherein the antibacterial agent comprises rottlerin; and   wherein the oral care composition is a dentifrice comprising from 0.01 weight % to 1.0 weight % rottlerin, based on the total weight of the oral care composition, wherein the rottlerin is present in an amount sufficient to reduce a growth of gram-positive bacteria.   
     
     
         9 . (canceled) 
     
     
         10 . The method of  claim 8 , wherein the oral care composition comprises from 0.05 weight % to 0.75 weight % rottlerin. 
     
     
         11 . The method of  claim 8 , wherein the antibacterial agent consists essentially of rottlerin. 
     
     
         12 . The method of  claim 8 , wherein the antibacterial effect comprises decreasing the growth of gram-positive oral bacteria in the mouth of a user of the oral care composition. 
     
     
         13 . (canceled) 
     
     
         14 . The oral care composition of  claim 1 , wherein the gram-positive bacteria is selected from:  S. oralis, S. mutans, A. viscosus  and combinations thereof. 
     
     
         15 . The method of  claim 12 , wherein the gram-positive oral bacteria is selected from:  S. oralis, S. mutans, A. viscosus  and combination thereof.