Method of enhancing a brain or cognitive function

Abstract

A composition for improving memory, learning ability, and cognitive ability and a method of enhancing a brain or cognitive function by administering the composition to a subject in need thereof. It has been confirmed that a peptide having a C-terminal region ended to GAG had an effect of improving the memory. In order for the peptide to have the effect, it has been confirmed that the peptide should be a peptide of which the length consists of at least 4 amino acids. Further, it has been confirmed that a peptide of which the length of the peptide having the C-terminal region ended to GAG consists of 5 to 9 amino acids has the same effect. As a result, the peptide of the present invention can be used as the composition for improving memory, learning ability, and cognitive ability, and the method of enhancing a brain or cognitive function.

What is claimed is: 
     
         1 . A method of enhancing a brain or cognitive function in a subject in need thereof, comprising administering a peptide consisting of SEQ ID NO: 4 (QGAG), SEQ ID NO:5 (GGAG), SEQ ID NO:8 (SGGAG), or SEQ ID NO:9 (GAGGAGGAG) to the subject. 
     
     
         2 . The method of  claim 1 , wherein the subject suffers from a memory, cognitive, or learning disorder caused by aging, Alzheimer's disease, schizophrenia, Parkinson's disease, Huntington's disease, pick disease, Creutzfeldt-Jakob disease, depression, head injury, stroke, CNS hypoxia, cerebral ischemia, encephalitis, forgetfulness, traumatic brain injury, hypoglycaemia, Wernicke-Korsakoff syndrome, drug addiction, epilepsy,  Fasciola hepatica , hippocampal sclerosis, headache, brain aging, dementia, frontotemporal lobar degeneration, tumor, normal pressure hydrocephalus, HIV, cerebrovascular disease, cerebral disease, cardiovascular disease, amnesia, radiation exposure, metabolic disease, hypothyroidism, mild cognitive impairment, cognitive deficiency, or attention deficit. 
     
     
         3 . The method of  claim 1 , wherein the peptide is administered in a food composition or a health drink composition to the subject. 
     
     
         4 . The method of  claim 1 , wherein the peptide is administered in a food composition, wherein said peptide is 0.01 to 15 wt % of the food composition. 
     
     
         5 . The method of  claim 1 , wherein the peptide is administered in a health drink composition, wherein the health drink composition contains the peptide at a concentration of 0.02 g to 5 g based on 100 ml of the health drink composition. 
     
     
         6 . The method of  claim 1 , wherein the peptide is administered in a health drink composition, wherein the health drink composition contains the peptide at a concentration of 0.3 g to 1 g based on 100 ml of the health drink composition. 
     
     
         7 . The method of  claim 1  wherein the peptide is administered in a food composition, wherein the food composition comprises a cytologically acceptable supplementary additive. 
     
     
         8 . The method of  claim 3 , wherein the food composition or health drink composition further contains one or more flavoring agents, starches, carbohydrates, nutrients, vitamins, minerals, electrolytes, coloring agents, thickening agents, pectic acid or a salt thereof, alginic acid or a salt thereof, an organic acid, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, and carbonic acid agents. 
     
     
         9 . The method of  claim 1 , wherein the peptide is administered in a health drink composition, wherein the health drink composition contains one or more carbohydrates at a concentration of 1 g to 20 g based on 100 ml of the health drink composition. 
     
     
         10 . The method of  claim 1 , wherein the peptide is administered in a food composition, wherein the food composition is in the form of a tablet, capsule, pill, liquid, jelly, powder, or granule. 
     
     
         11 . The method of  claim 3 , wherein the food composition or health drink composition comprises one or more monosaccharides, disaccharides, polysaccharides, and sugar alcohols. 
     
     
         12 . The method of  claim 3 , wherein the food composition or health drink composition comprises one or more of glucose, fructose, maltose, sucrose, dextrin, cyclodextrin, xylitol, sorbitol, erythritol, thaumatin, stevia extract, saccharin, and aspartame. 
     
     
         13 . The method of  claim 3 , wherein the food composition or health drink composition comprises one or more of rebaudioside A, glycyrrhizin, cheese, chocolate, fruit juice, and vegetable juice. 
     
     
         14 . The method of  claim 1 , wherein the peptide consists of SEQ ID NO: 4 (QGAG). 
     
     
         15 . The method of  claim 1 , wherein the peptide consists of SEQ ID NO:5 (GGAG). 
     
     
         16 . The method of  claim 1 , wherein the peptide consists of SEQ ID NO:8 (SGGAG). 
     
     
         17 . The method of  claim 1 , wherein the peptide consists of SEQ ID NO:9 (GAGGAGGAG).